San Diego Padres @ San Francisco Giants Player Props, Picks and Predictions - 6/5/2025 3:45 PM EDT

We have your San Diego Padres @ San Francisco Giants prop betting and game preview needs covered as the San Francisco Giants hit the road to face the San Diego Padres.

San Diego Padres @ San Francisco Giants Pick

Best Moneyline Odds: San Diego Padres -115, San Francisco Giants -105.
Best Total Odds: Over/Under 7.0 runs (-110).

Game Info

Date: June 5, 2025
Time: 3:45 PM EDT
Location: Oracle Park, San Francisco, CA
TV: -

San Diego Padres @ San Francisco Giants Preview

The San Diego Padres (35-25) and San Francisco Giants (34-28) are set to clash in a pivotal NL West matchup. The Padres are slight favorites heading into this game, despite the Giants playing at home. Both teams are coming off a tightly contested game on June 4, where the Giants edged out the Padres 6-5. This game is expected to be another close battle, with both teams vying for divisional supremacy.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on June 4, 2025, the San Francisco Giants defeated the San Diego Padres 6-5 in a nail-biter. Over their last 10 meetings, the series has been evenly matched, with both teams trading wins. The Giants have shown resilience at Oracle Park, leveraging their home-field advantage effectively. However, the Padres have been competitive on the road, making this matchup a toss-up.

Pick: Total Under 7.0 Runs (-110)

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This game is projected to be a low-scoring affair, as both teams have strong pitching staffs and have been involved in tight games recently. The total has gone under in several of their recent matchups, and with the line set at 7.0 runs, the under presents value. Expect a pitching duel to dictate the pace of the game.

Top Player Prop Picks

1. Logan Webb Over 6.5 Strikeouts (-115)

Logan Webb has been a strikeout machine, consistently hitting this mark in recent starts. Facing a Padres lineup that has struggled with strikeouts against right-handed pitchers, Webb is in a prime position to dominate on the mound.

2. Fernando Tatis Jr. Over 1.5 Total Bases (+120)

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Fernando Tatis Jr. has been a key offensive contributor for the Padres, and his ability to hit for extra bases makes this prop appealing. He has a favorable matchup against the Giants' pitching staff and could easily surpass this line.

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