Indiana State Sycamores @ Indiana Hoosiers Player Props, Picks and Predictions - 9/12/2025 6:30 PM EDT

We have your Indiana State Sycamores @ Indiana Hoosiers prop betting and game preview needs covered as the Indiana State Sycamores hit the road to face the Indiana Hoosiers.

Game Info

Date: 9/12/2025
Time: 6:30 PM EDT
Location: -
TV: -

Indiana State Sycamores @ Indiana Hoosiers Preview

The Indiana Hoosiers are set to host the Indiana State Sycamores in a matchup where the Hoosiers are expected to assert their dominance. Indiana State has shown some improvement from their 2024 season, notably turning a 27-20 defeat at Eastern Illinois last season into a 38-14 victory over the Panthers this past Saturday. However, their track record against FBS opponents has not been competitive since a close defeat to Kansas in 2019.

Indiana, currently 2-0, enters this game with clear objectives: move to 3-0, ensure player health, and provide valuable snaps for their backup talent. This suggests the Hoosiers aim for a commanding victory. Their rushing attack has been a significant strength, accumulating over 300 yards against both Old Dominion and Kennesaw State, averaging an impressive 6.48 yards per carry. Running backs Roman Hemby (5.47 YPC), Kaelon Black (5.52 YPC), and Lee Beebe (7.41 YPC) have all been highly effective.

On the Indiana State side, a major blow comes with the injury to starting quarterback and second-leading rusher Elijah Owens, who suffered a collarbone injury and will miss this contest. Redshirt junior Keegan Patterson is expected to step in. Patterson performed well against Eastern Illinois, throwing for 111 yards with two touchdowns and rushing for another 78, but facing the Hoosiers' defense presents a much tougher challenge. While Indiana State's run defense has been solid against lesser opponents (2 YPC at Eastern Illinois, 3.5 YPC at McKendree), it will be severely tested by Indiana's powerful ground game.

Historic Head-to-Head Stats and Analysis

Historically, matchups between these two programs have heavily favored the Indiana Hoosiers. In a recent encounter, Tom Allen’s Indiana team secured a decisive 41-7 victory over Indiana State. Furthermore, Purdue, another Big Ten opponent, handled the Sycamores with a 49-0 shutout last season. These results underscore a consistent trend: Indiana State has struggled to be competitive against FBS opponents, a pattern that dates back to a close defeat against Kansas in 2019.

Pick: Indiana Hoosiers to win decisively

While specific betting lines for this matchup are not available in our research, the Indiana Hoosiers are heavily favored to dominate the Indiana State Sycamores. Historically, Indiana State has struggled significantly against FBS opponents, and the Hoosiers have a track record of large victories in similar matchups. Indiana's powerful rushing attack, averaging 6.48 yards per carry and over 300 rushing yards in their first two games, is expected to overwhelm Indiana State's defense, despite their decent run defense stats against lesser opponents. Furthermore, Indiana State will be without their starting quarterback and second-leading rusher, Elijah Owens, due to a collarbone injury, forcing redshirt junior Keegan Patterson into the starting role. This quarterback change, coupled with Indiana's superior talent and depth, sets the stage for a comfortable Hoosiers victory.

Top Player Prop Picks

Specific player prop lines and odds for this game are not available in our research. However, based on the game preview, here are some players whose performances would be interesting to monitor for potential prop opportunities:

Indiana Hoosiers Running Backs - Over Rushing Yards

The Indiana Hoosiers have established a dominant ground game, averaging 6.48 yards per carry and exceeding 300 rushing yards in each of their first two games. Key backs like Roman Hemby (5.47 YPC), Kaelon Black (5.52 YPC), and Lee Beebe (7.41 YPC) have been highly efficient. Against an Indiana State defense that, despite some early season success against lower-tier opponents, is expected to be overwhelmed by Indiana's offensive line, any of these backs could be in for a big day. If lines were available, targeting the 'Over' on their individual rushing yard totals would be a strong consideration, especially given Indiana's stated goal of running the ball and getting their backs significant carries.

Indiana State Sycamores QB Keegan Patterson - Under Passing Yards

With starting quarterback Elijah Owens sidelined due to injury, redshirt junior Keegan Patterson steps in for Indiana State. While Patterson performed adequately against Eastern Illinois, throwing for 111 yards and two touchdowns, facing the Indiana Hoosiers' defense is a significant step up in competition. Indiana is expected to apply heavy pressure, and their defensive line should be able to overwhelm the Sycamores' offensive line. This could limit Patterson's time in the pocket and force quick, potentially inaccurate throws. If a passing yards prop were available, the 'Under' would be a logical play given the circumstances and the strength of the opponent.

Indiana Hoosiers Backup Skill Players - Over Receiving/Rushing Yards

Indiana's coaching staff has indicated a desire to get valuable snaps for backup players in this game, especially if the game gets out of hand early. This includes running backs like Khobie Martin and Sean Cuono, and wide receivers such as Lebron Bond, Charlie Becker, and Davion Chandler. If the Hoosiers build a substantial lead, these players could see extended playing time in the second half, potentially accumulating significant yardage. While specific lines are not available, monitoring their usage and considering 'Over' props on their individual yardage totals, particularly in the second half, could be a strategic move if such options were offered.