Chicago Cubs @ San Diego Padres Player Props, Picks and Predictions - 4/16/2025 4:10 PM EDT

We have your Chicago Cubs @ San Diego Padres prop betting and game preview needs covered as the San Diego Padres hit the road to face the Chicago Cubs.

Chicago Cubs @ San Diego Padres Pick

Best Moneyline Odds: Chicago Cubs -156, San Diego Padres +132.
Best Total Odds: Over/Under 8 runs (-105 on the Over).

Game Info

Date: April 16, 2025
Time: 4:10 PM EDT
Location: Wrigley Field, Chicago, IL
TV: -

Chicago Cubs @ San Diego Padres Preview

The Chicago Cubs and San Diego Padres face off in the second game of their series at Wrigley Field. The Cubs took the first game in a tight 2-1 victory, showcasing their pitching depth and defensive prowess. Chicago has been strong as a moneyline favorite this season, boasting a 7-2 record in such situations. Meanwhile, the Padres have been competitive, winning four of their last seven games as underdogs. Both teams are looking to gain momentum in this early-season matchup, with the Cubs aiming to extend their home dominance and the Padres seeking to bounce back offensively.

Historic Head-to-Head Stats and Analysis

In their recent head-to-head matchups, the Cubs and Padres have been evenly matched. On April 6, 2025, the Padres edged out the Cubs in an 8-7 thriller, while the Cubs responded with a commanding 7-1 victory on April 5, 2025. Last night’s game saw the Cubs secure a narrow 2-1 win, highlighting their ability to win close contests. Historically, these games have been competitive, with both teams trading wins and showcasing strong pitching performances.

Pick: Chicago Cubs Moneyline (-156)

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The Cubs have been reliable as moneyline favorites, winning 77.8% of such games this season. Their pitching staff has been dominant, as evidenced by their ability to hold the Padres to just one run in the series opener. With home-field advantage and a strong track record in similar situations, the Cubs are the safer pick to win outright.

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