Baltimore Orioles @ Cleveland Guardians Player Props, Picks and Predictions - 7/21/2025 6:40 PM EDT

We have your Baltimore Orioles @ Cleveland Guardians prop betting and game preview needs covered as the Baltimore Orioles hit the road to face the Cleveland Guardians.

Baltimore Orioles @ Cleveland Guardians Pick

Best Moneyline Odds: Baltimore Orioles +122 | Cleveland Guardians -136
Best Spread Odds: -
Best Total Odds: -

Game Info

Date: 2025-07-21
Time: 6:40 PM EDT
Location: Cleveland, Ohio
TV: -

Baltimore Orioles @ Cleveland Guardians Preview

The Cleveland Guardians, with a season record of 48-50, are set to host the Baltimore Orioles, who currently stand at 44-54. Both teams are looking to improve their standings as they are currently below the .500 mark. The Guardians come into this game with a home record of 20-23, while the Orioles have struggled slightly more on the road, holding a 21-27 record away from home. Cleveland recently secured a series win against the Athletics, taking two out of three games with scores of 8-6, 2-8, and 8-2, showing some recent momentum at the plate. The Guardians are considered solid favorites for this matchup.

Historic Head-to-Head Stats and Analysis

In their previous encounters this season, the Baltimore Orioles managed to win two out of three games against the Cleveland Guardians back in April. This indicates that despite the Guardians being the favored team in this upcoming matchup, the Orioles have shown they can compete and secure victories against them.

Pick: Cleveland Guardians Moneyline

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The Cleveland Guardians are favored in this matchup, and for good reason. They hold a slightly better overall record than the Orioles and will be playing on their home turf in Cleveland, where they have shown a decent performance this season. Their recent series win against the Athletics also suggests they are coming into this game with some positive momentum. While the Orioles did win their last series against the Guardians in April, the home advantage and recent form lean towards Cleveland for this contest.

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