Here is the Pickwatch BetSmart Preview for the Tulane Green Wave vs. Ole Miss Rebels game in Round 1 of the 2025 College Football Playoffs.

Tulane Green Wave vs. Ole Miss Rebels Game Info

Date: Saturday, December 20, 2025
Time: 3:30 PM ET
Location: Vaught-Hemingway Stadium (Oxford, MS)
TV: TNT / TruTV

Tulane vs. Ole Miss Betting Odds

Point Spread
- Tulane +17.5
- Ole Miss -17.5
Moneyline
- Tulane +610
- Ole Miss -900
Total
- Over/Under 50.5

Season Betting Records

Moneyline
- Tulane: 11-2
- Ole Miss: 11-1
Against the Spread
- Tulane: 7-5
- Ole Miss: 6-6-1
Totals (Over-Under)
- Tulane: 4-9
- Ole Miss: 6-6

No. 11 Tulane (11-2) @ No. 6 Ole Miss (11-1) Preview

This is the weirdest vibe game of the weekend because it’s not just “Ole Miss hosting a playoff game”—it’s Ole Miss doing it amid a coaching transition. Lane Kiffin left for LSU, and Pete Golding is now leading the program into its CFP debut. The question is how much that changes the offensive feel and in-game decision-making when the pressure spikes.

The injury report for this game features some key players. Ole Miss listed several players out (including Cedrick Beavers and Raymond Collins) plus a couple questionable; Tulane listed multiple outs including Dickson Agu (LB), LeRon Husbands (TE), and others. Those Tulane outs matter if the Green Wave needs to steal hidden yards (special teams) and survive in pass protection.

These teams already played once this season, and Ole Miss won big (the storyline across previews is that Tulane is better than that first score showed, but the talent gap is still real). Tulane’s path usually requires (1) shortening the game, (2) winning situational downs, and (3) forcing Ole Miss into a couple of “why did you do that?” moments that new staffs can be vulnerable to in their first CFP experience.

Oxford’s forecast is a little messy across feeds—overall it looks mild-to-warm for December, with low rain risk and light-to-moderate wind. If conditions stay calm, this is the slate’s best setup for offensive rhythm (especially compared to Norman).

Things to watch for: (1) whether Ole Miss comes out conservative (coach-transition nerves) or fast (statement intent), (2) Tulane’s ability to tackle in space for four quarters, and (3) whether Ole Miss’ run game can turn this into a second-half avalanche (which the spread implies).

BetSmart Betting Rundown

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NOTE: All available bets are as of time of publication. Odds and lines change often, so be sure to check each subsequent Pickwatch betting tool for the latest numbers.

Arbitrage

Our Arbitrage Betting Tool is currently identifying 1 arbitrage betting opportunity for guaranteed profit.

Middles

Our Middle Betting Tool is currently identifying 2 middle betting opportunities.

Positive EV

Our Positive EV Betting Tool is currently identifying 3 different positive expected value wagers, and provided data on the expected value percentrage, and how often the bet has hit in the last 5, 10 and 15 games.

Tulane vs. Ole Miss: Expert Picks

Visit our Expert Picks page to view picks and data from our tracked experts to see where the consensus is on the Tulane vs. Ole Miss moneyline, point spread and total points.