St. Louis Cardinals @ Chicago White Sox Player Props, Picks and Predictions - 6/18/2025 7:40 PM EDT

We have your St. Louis Cardinals @ Chicago White Sox prop betting and game preview needs covered as the St. Louis Cardinals hit the road to face the Chicago White Sox.

St. Louis Cardinals @ Chicago White Sox Pick

Best Moneyline Odds: St. Louis Cardinals -192, Chicago White Sox +160.
Best Spread Odds: St. Louis Cardinals -1.5 (-118), Chicago White Sox +1.5 (-102).
Best Total Odds: Over 8.5 (+110), Under 8.5 (-132).

Game Info

Date: June 18, 2025
Time: 7:40 PM EDT
Location: Guaranteed Rate Field, Chicago, IL
TV: -

St. Louis Cardinals @ Chicago White Sox Preview

The St. Louis Cardinals (38-35) continue their road trip as they face the struggling Chicago White Sox (23-50) in the second game of their interleague series. The Cardinals are coming off a dominant 12-2 victory in the series opener, showcasing their offensive firepower. Meanwhile, the White Sox are looking to bounce back after a tough loss and improve their dismal season record. With the Cardinals aiming to solidify their position in the standings and the White Sox desperate for a win, this matchup promises to be an intriguing battle.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on June 17, 2025, the St. Louis Cardinals routed the Chicago White Sox 12-2, demonstrating their offensive dominance. Historically, the Cardinals have had the upper hand in this interleague rivalry, consistently outperforming the White Sox in recent meetings. The White Sox will need to address their pitching struggles to stand a chance against the Cardinals' potent lineup.

Pick: St. Louis Cardinals Moneyline (-192)

widget-odds-mlb-su-11218-STL-CHW

The Cardinals are the clear favorites in this matchup, and for good reason. Their offense is firing on all cylinders, as evidenced by their 12-run outburst in the previous game. The White Sox, on the other hand, have struggled mightily this season, with a 23-50 record and a lack of consistency on both offense and defense. Backing the Cardinals on the moneyline is the safest play here, given their recent form and the White Sox's ongoing struggles.

Top Player Prop Picks

1. Paul Goldschmidt Over 1.5 Total Bases

Goldschmidt has been a key contributor for the Cardinals, and his ability to rack up extra-base hits makes this prop appealing. With the White Sox's pitching staff struggling, Goldschmidt is in a prime position to exceed this line.

2. Nolan Arenado to Record an RBI

widget-props-mlb-11218-5612451

Arenado has been a consistent run producer for the Cardinals, and with the team’s offense clicking, he should have plenty of opportunities to drive in runs against a vulnerable White Sox pitching staff.

3. Dylan Cease Over 5.5 Strikeouts

Despite the White Sox's struggles, Cease remains a bright spot in their rotation. He has the ability to rack up strikeouts, and even against a strong Cardinals lineup, this line is within reach for the talented right-hander.

New customer offers and more lines available at:

Free Picks available for new customers at: