Here is the Pickwatch BetSmart Preview for the San Francisco 49ers vs. Philadelphia Eagles game in the Wild Card Round of the NFL Playoffs.

San Francisco 49ers vs. Philadelphia Eagles Game Info

Date: Sunday, January 11, 2025
Time: 4:30 PM ET
Location: Lincoln Financial Field — Philadelphia, Pennsylvania
TV: FOX

49ers vs. Eagles Betting Odds

Point Spread
- 49ers +5.5
- Eagles -5.5
Moneyline
- 49ers +225
- Eagles -275
Total
- Over/Under 44.5

Season Betting Records

Moneyline
- 49ers: 12-5
- Eagles: 11-6
Against the Spread
- 49ers: 10-6-1
- Eagles: 10-7
Totals (Over-Under)
- 49ers: 10-6-1
- Eagles: 7-10

San Francisco 49ers (12-5) @ Philadelphia Eagles (11-6) Preview

This is the marquee matchup of the weekend. San Francisco brings one of the league’s most balanced rosters into Philadelphia, pairing a physical run game with efficient play-action passing. Their ability to stay patient and avoid turnovers gives them a legitimate chance on the road.

Philadelphia counters with intensity, depth, and a hostile home environment. The Eagles’ defensive front can control games when they win early downs, and their offense thrives when able to dictate tempo. Home-field energy will be a major factor, particularly early.

This game likely swings on trench play and situational execution. If the Eagles control the line of scrimmage, they can pull away. If San Francisco stays balanced and limits mistakes, this could become a late-game classic decided by one or two key plays. As for weather, expect cold and breezy temps in the 30s with possible wind gusts, which could hurt deep passing.

A chilly Philly environment could force both teams to lean on run and short passing early. San Francisco brings a balanced, methodical attack designed to control tempo and limit mistakes. Philadelphia counters with a physical defense and opportunistic pass rush. If the 49ers can stay ahead of schedule and use play-action, they’ll take pressure off their run game; if the Eagles get an early lead, they can lean on clock control and defense.

49ers/Eagles Head-to-Head (H2H) Stats and Analysis

The San Francisco 49ers lead the all-time series 21-15-1 against the Philadelphia Eagles. Here are the last 5 meetings:

San Francisco 49ers 42, Philadelphia Eagles 19 — December 3, 2023
Philadelphia Eagles 31, San Francisco 49ers 7 — January 29, 2023 (NFC Championship)
San Francisco 49ers 17, Philadelphia Eagles 11 — September 19, 2021
Philadelphia Eagles 25, San Francisco 49ers 20 — October 4, 2020
Philadelphia Eagles 33, San Francisco 49ers 10 — October 29, 2017

BetSmart Betting Rundown

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NOTE: All available bets are as of time of publication. Odds and lines change often, so be sure to check each subsequent Pickwatch betting tool for the latest numbers.

Arbitrage

Our Arbitrage Betting Tool is currently identifying 3 arbitrage betting opportunities for guaranteed profit.

Middles

Our Middle Betting Tool is currently identifying 41 middle betting opportunities.

Positive EV

Our Positive EV Betting Tool is currently identifying 6 different positive expected value wagers, and provided data on the expected value percentrage, and how often the bet has hit in the last 5, 10 and 15 games.

Player Props

Our Prop Finder Tool is currently identifying 305 different player prop bets, and provided data on how often each player has hit the specific prop in the last 5, 10 and 15 games.

49ers vs. Eagles: Expert Picks

Visit our Expert Picks page to view picks and data from over 200 experts to see where the consensus is on the 49ers vs. Eagles moneyline, point spread and total points.