San Francisco 49ers at Tampa Bay Buccaneers Player Props, Picks and Predictions - 11/10/2024 1:00 PM EST

We have your San Francisco 49ers at Tampa Bay Buccaneers prop betting and game preview needs covered as the San Francisco 49ers hit the road to face the Tampa Bay Buccaneers.

San Francisco 49ers at Tampa Bay Buccaneers Odds Info

Best Moneyline Odds: San Francisco 49ers -280 (ESPN BET) / Tampa Bay Buccaneers +230 (ESPN BET)
Best Spread Odds: 6.0 - San Francisco 49ers -105 (DraftKings) / Tampa Bay Buccaneers -115 (DraftKings)
Best Total Odds: 48.5 - Under -114 (FanDuel) / Over -106 (FanDuel)

Game Info

Date: 11/10/2024
Time: 1:00 PM EST
Location: Raymond James Stadium (Tampa, FL)
TV: FOX

Historic Head-to-Head Stats and Analysis

Over the past two seasons, the San Francisco 49ers and the Tampa Bay Buccaneers have faced off twice, with both games resulting in victories for the 49ers. The games were played on December 11, 2022, and November 19, 2023, with San Francisco hosting both matchups. In these encounters, the home team emerged victorious each time, and the 49ers covered the spread once, while the Buccaneers managed to cover the spread in the other game. The total score went over the set line in one game and under in the other, indicating a balanced outcome in terms of scoring expectations. The 49ers have consistently outperformed the Buccaneers in these matchups, maintaining a perfect record against them during this period.

The most recent game on November 19, 2023, saw the San Francisco 49ers secure a 27-14 victory over the Tampa Bay Buccaneers. The 49ers, favored with a closing spread of -13.5, managed to win the game but did not cover the spread, as the Buccaneers were able to keep the margin within 13 points. San Francisco's quarterback, Brock Purdy, delivered an impressive performance, completing 21 of 25 passes for 333 yards and three touchdowns. The 49ers' offense accumulated a total of 420 yards, while their defense limited the Buccaneers to 287 yards. Despite Tampa Bay's efforts, including a 1-yard rushing touchdown by Rachaad White in the fourth quarter, the 49ers maintained control throughout the game, leading in time of possession and first downs.

In the earlier matchup on December 11, 2022, the 49ers dominated the Buccaneers with a decisive 35-7 victory. San Francisco, again the home favorite, easily covered the spread, which closed at -3.5. The 49ers' offense was balanced, with 209 rushing yards and 195 passing yards, resulting in five total touchdowns. The Buccaneers struggled offensively, managing only 322 total yards and committing three turnovers. San Francisco's defense was effective, intercepting two passes and holding Tampa Bay to a single touchdown. This game saw the total score exceed the over-under line, highlighting the 49ers' offensive prowess and defensive strength in their comprehensive win.

San Francisco 49ers at Tampa Bay Buccaneers Preview

The San Francisco 49ers are set to face the Tampa Bay Buccaneers in a Week 10 matchup that promises to be a compelling contest. The 49ers, coming off a bye week, are looking to capitalize on their rest advantage and the potential return of star running back Christian McCaffrey. McCaffrey, who has been sidelined with Achilles tendinitis, is expected to make his season debut, providing a significant boost to a 49ers offense that has struggled with red zone efficiency in his absence. His return could be pivotal, especially given the recent season-ending injury to wide receiver Brandon Aiyuk.

San Francisco enters the game with a 4-4 record, matching that of the Buccaneers, but the 49ers have shown resilience despite their injury woes. The team has relied on the impressive performances of Jordan Mason in the backfield, who has stepped up admirably in McCaffrey's absence. The 49ers' defense, known for its tenacity, will look to stifle a Buccaneers offense that has been hampered by injuries to key players like Mike Evans and Chris Godwin. With both receivers out, Tampa Bay's offensive options are limited, placing additional pressure on quarterback Baker Mayfield to deliver against a formidable San Francisco defense.

The Buccaneers, on the other hand, are coming off a narrow overtime loss to the Kansas City Chiefs, a game that highlighted their ability to compete despite being short-handed. Mayfield has been efficient, completing a high percentage of his passes, but the absence of his top targets could prove challenging against a 49ers defense that excels in limiting big plays. Tampa Bay's defense, which has struggled against tight ends, will need to find a way to contain Travis , who remains a key weapon for the 49ers.

As the 49ers travel to Raymond James Stadium, they will need to overcome the challenges of playing in the eastern timezone, a factor that could level the playing field. However, with McCaffrey's anticipated return and the Buccaneers' injury concerns, San Francisco appears poised to take advantage of the situation. The 49ers' ability to execute their game plan and capitalize on Tampa Bay's vulnerabilities will be crucial in determining the outcome of this matchup.

San Francisco 49ers at Tampa Bay Buccaneers Pick: San Francisco 49ers Moneyline

The San Francisco 49ers are poised to secure a victory against the Tampa Bay Buccaneers in their Week 10 matchup, making the 49ers moneyline a compelling pick. The 49ers are coming off a bye week, which has provided them with a crucial rest advantage and the opportunity to reintegrate star running back Christian McCaffrey into their lineup. McCaffrey's return is expected to significantly bolster San Francisco's offensive capabilities, particularly in the red zone where they have struggled in his absence. His presence on the field is likely to rejuvenate an offense that has been missing his dynamic playmaking ability.

Despite their 4-4 record, the 49ers have demonstrated resilience, largely due to the impressive performances of Jordan Mason, who has admirably filled in for McCaffrey. The 49ers' defense, known for its tenacity, will be a formidable challenge for a Buccaneers offense that is severely hampered by injuries to key players like Mike Evans and Chris Godwin. With both receivers sidelined, Tampa Bay's offensive options are limited, placing additional pressure on quarterback Baker Mayfield to perform against a San Francisco defense that excels in limiting big plays.

The Buccaneers, while showing grit in their recent overtime loss to the Kansas City Chiefs, face a daunting task against a 49ers team that is well-rested and reinforced. Mayfield has been efficient, but the absence of his top targets could prove insurmountable against a defense as robust as San Francisco's.

While the 49ers must contend with the challenges of playing in the eastern timezone, their overall advantages in personnel and preparation make them the favorites in this matchup. With McCaffrey's anticipated return and the Buccaneers' injury concerns, San Francisco is well-positioned to capitalize on the situation and secure a win. The 49ers' ability to execute their game plan and exploit Tampa Bay's vulnerabilities will be crucial in determining the outcome, making the 49ers moneyline a strong pick for this contest.

San Francisco 49ers at Tampa Bay Buccaneers Top Player Prop Picks

Christian McCaffrey Over 75.5 Rushing Yards (-110) (DraftKings)

Christian McCaffrey's anticipated return to the field is a significant boost for the San Francisco 49ers, and his impact is expected to be immediate. Despite missing the first half of the season due to Achilles tendinitis, McCaffrey's track record as the reigning NFL Offensive Player of the Year speaks volumes. Last season, he led the league with 1,459 rushing yards, averaging 5.4 yards per carry. The 49ers have been effective on the ground even in his absence, ranking fourth in the NFL in rushing yards per game. With McCaffrey back, the 49ers' rushing attack is poised to be even more potent, especially against a Buccaneers defense that has struggled with injuries and has shown vulnerability. Given McCaffrey's ability to break big plays and his importance in the 49ers' offensive scheme, betting on him to surpass 75.5 rushing yards is a strong proposition.

Baker Mayfield Under 250.5 Passing Yards (-115) (FanDuel)

Baker Mayfield has been efficient this season, completing a career-high 71.1% of his passes. However, the absence of his top targets, Mike Evans and Chris Godwin, severely limits his options against a formidable 49ers defense. San Francisco's defense is known for its ability to limit big plays and apply pressure, which could disrupt Mayfield's rhythm. The Buccaneers' offense, already hampered by injuries, faces a tough challenge against a 49ers team that excels in defensive coverage and pass rush. With Mayfield's primary receivers sidelined, it will be difficult for him to reach 250.5 passing yards, making the under a compelling choice.