New York Mets @ Washington Nationals Player Props, Picks and Predictions - 8/21/2025 4:05 PM EDT

We have your New York Mets @ Washington Nationals prop betting and game preview needs covered as the New York Mets hit the road to face the Washington Nationals.

New York Mets @ Washington Nationals Pick

Best Moneyline Odds: New York Mets -130 on BetMGM
Best Spread Odds: New York Mets -1.0 (-106) on BetRivers
Best Total Odds: Over 8.0 (-118) on BetMGM

Game Info

Date: 2025-08-21
Time: 4:05 PM EDT
Location: Nationals Park, Washington D.C.
TV: -

New York Mets @ Washington Nationals Preview

The New York Mets (67-59) travel to Nationals Park to conclude their series against the Washington Nationals (51-75). The Mets are currently second in the NL East standings and are looking to solidify their playoff push, while the Nationals are at the bottom of the division. The Mets have shown a strong offensive output recently, averaging 6.5 runs per game over their last five contests, though their pitching has seen a 4.09 ERA in that same span. The Nationals, despite their overall record, have been competitive lately, holding a 5-5 record in their last 10 games, matching the Mets' recent performance. However, their pitching has struggled with a 5.60 ERA over their last five games.

On the mound, the Mets will send left-hander Sean Manaea (1-1, 4.78 ERA) to the hill. Manaea has faced some challenges recently, allowing 13 earned runs over his last 14.2 innings across three starts. However, he has historically performed well against the Nationals, allowing just one earned run in each of his last two starts against them. For the Nationals, left-hander MacKenzie Gore (5-12, 4.04 ERA) gets the start. Gore has also been in a slump, posting a 1-4 record with a 6.04 ERA in his last five outings. He has struggled against the Mets specifically, losing his last three starts against them and giving up an average of 2.3 runs per game.

A key storyline for the Mets is the status of Brandon Nimmo, who is considered day-to-day with a stiff neck after leaving Wednesday's game. His absence could impact the Mets' lineup depth. The Mets' offense ranks 8th in home runs and 7th in On-Base Percentage (OBP) this season, while the Nationals' offense ranks 20th in runs per game. The Mets are projected to score 4.27 runs compared to the Nationals' 3.73 runs.

Historic Head-to-Head Stats and Analysis

The New York Mets and Washington Nationals have a rich history of matchups. In their most recent encounter on August 20, 2025, the Nationals secured a narrow 5-4 victory. Historically, the Nationals boast 74 wins in head-to-head clashes, with 41 of those triumphs coming on their home turf. The New York Mets, however, hold the overall edge in the series, having claimed victory in 94 games, including 41 on the road. This season, the Mets lead the series 6-3 against the Nationals. When playing at Nationals Park in 2025, the teams have split their contests evenly, with a 3-3 record. In their last three meetings, the Mets have averaged 5.33 runs per game while limiting the Nationals to just 3.00 runs per game.

Pick: New York Mets Moneyline

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Despite some recent struggles from Sean Manaea, the New York Mets present a strong betting opportunity on the moneyline. The Mets are battling for a playoff spot and have a superior overall record (67-59) compared to the Nationals (51-75). While both teams have gone 5-5 in their last 10 games, the Mets have a significant advantage in the pitching matchup. MacKenzie Gore, the Nationals' starter, has been in poor form recently, with a 6.04 ERA over his last five starts, and has a history of struggling against the Mets. The Mets also hold a dominant 5-1 straight-up record in their last six games against Washington and lead the season series 6-3. The sharp money also favors the Mets on the moneyline, with a 55.03% sharp win percentage. Given the Mets' motivation, their historical dominance in this matchup, and Gore's recent struggles, New York is poised to take this rubber match.

Top Player Prop Picks

Paul DeJong Over 0.5 Bases

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Paul DeJong has been on an impressive hitting streak, consistently exceeding his bases prop. He has hit the over in 100% of his last 5 games and 90% of his last 10 games, demonstrating strong recent form. Furthermore, DeJong has performed exceptionally well against the Mets this season, hitting the over in both of his matchups against them. Playing at home, he maintains a solid 66.67% hit rate for this prop. With a line of 0.5 bases and odds of -135 on Caesars, DeJong is a strong candidate to continue his hot streak.

Juan Soto Over 1.5 Hits + Runs + RBIs

Juan Soto has been a consistent offensive force for the New York Mets, making his Hits + Runs + RBIs prop an attractive pick. He has hit the over in 80% of his last 10 games and 73.33% of his last 15 games, showcasing his ability to contribute across multiple categories. Against the Washington Nationals this season, Soto has been particularly effective, hitting the over in 77.78% of his 9 appearances. With a line of 1.5 and odds of -110 on BetMGM, Soto is well-positioned for another productive outing.

Francisco Lindor Over 1.5 Hits + Runs + RBIs

Francisco Lindor enters this game in excellent form, making the over on his Hits + Runs + RBIs prop a compelling choice. He has hit the over in 100% of his last 5 games and 80% of his last 10 games, indicating a high level of recent performance. While his season average against the Nationals is 55.56% over 9 games, his current hot streak suggests he is poised to exceed expectations. With a line of 1.5 and odds of -130 on BetMGM, Lindor is a strong pick to contribute significantly to the Mets' offense.