Here is the Pickwatch BetSmart Preview for the James Madison Dukes vs. Oregon Ducks game in Round 1 of the 2025 College Football Playoffs.

James Madison Dukes vs. Oregon Ducks Game Info

Date: Saturday, December 20, 2025
Time: 7:30 PM ET
Location: Autzen Stadium (Eugene, OR)
TV:TNT / TruTV

James Madison vs. Oregon Betting Odds

Point Spread
- JMU +20.5
- Oregon -20.5
Moneyline
- JMU +1200
- Oregon -2500
Total
- Over/Under 47.5

Season Betting Records

Moneyline
- JMU: 12-1
- Oregon: 11-1
Against the Spread
- JMU: 8-5
- Oregon: 8-4
Totals (Over-Under)
- JMU: 5-8
- Oregon: 6-6

No. 12 James Madison (12-1) vs. No. 5 Oregon (11-1) Preview

This is the classic “can the underdog make it uncomfortable?” playoff spot. Oregon is a huge favorite, but James Madison isn’t a typical 12 seed profile—FanDuel’s basic team profile stats have both offenses scoring a lot and both defenses ranking well by points allowed, which hints at a game where efficiency can keep things tighter than the logo test suggests.

Oregon’s injury reports have included several receivers and defensive backs listed as probable/questionable in coverage this week. That matters less if Oregon can live in “run + play-action” mode, but it matters a lot if weather forces the passing game into high-degree-of-difficulty throws and contested catches.

How can JMU hang around? The first quarter is everything. If JMU can avoid a quick multi-score hole, the pressure flips to Oregon to justify the spread while dealing with rain, noise, and limited possessions. Oregon’s best path is the boring one: win early downs, protect the ball, force JMU into long-yardage, and let Autzen do the rest.

BetSmart Betting Rundown

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NOTE: All available bets are as of time of publication. Odds and lines change often, so be sure to check each subsequent Pickwatch betting tool for the latest numbers.

Arbitrage

Our Arbitrage Betting Tool is currently identifying 2 arbitrage betting opportunities for guaranteed profit.

Middles

Our Middle Betting Tool is currently identifying 3 middle betting opportunities.

Positive EV

Our Positive EV Betting Tool is currently identifying 2 positive expected value wagers, and provided data on the expected value percentrage, and how often the bet has hit in the last 5, 10 and 15 games.

James Madison vs. Oregon: Expert Picks

Visit our Expert Picks page to view picks and data from all of our tracked experts to see where the consensus is on the James Madison vs. Oregon moneyline, point spread and total points.