Detroit Tigers @ St. Louis Cardinals Player Props, Picks and Predictions - 5/21/2025 1:15 PM EDT

We have your Detroit Tigers @ St. Louis Cardinals prop betting and game preview needs covered as the St. Louis Cardinals hit the road to face the Detroit Tigers.

Detroit Tigers @ St. Louis Cardinals Pick

Best Moneyline Odds: Tigers -105, Cardinals +150.
Best Spread Odds: Tigers -1.5 (+140), Cardinals +1.5 (-160).
Best Total Odds: Over 8.5 (-110), Under 8.5 (-110).

Game Info

Date: May 21, 2025
Time: 1:15 PM EDT
Location: Comerica Park, Detroit, MI
TV: Local Broadcast Networks

Detroit Tigers @ St. Louis Cardinals Preview

The Detroit Tigers and St. Louis Cardinals face off in the final game of their series. The Tigers are coming off a narrow 5-4 victory in the previous game, showcasing their ability to edge out close contests. Both teams have been inconsistent this season, making this matchup a pivotal one for momentum. The Tigers' offense has been led by timely hitting, while the Cardinals rely on their pitching depth to keep games close. Expect a competitive game as both teams aim to secure a series win.

Historic Head-to-Head Stats and Analysis

In their last three matchups, the Tigers and Cardinals have alternated wins, with the Tigers taking the most recent game 5-4. On May 19, 2025, the Cardinals dominated with an 11-4 victory, while the Tigers bounced back on May 20, 2025. Historically, these teams have played tight games, with the Tigers slightly edging the Cardinals in recent meetings. The Cardinals have been more successful as favorites, but the Tigers have shown resilience as underdogs.

Pick: Tigers Moneyline (-105)

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The Tigers have shown they can compete in close games, and their recent victory over the Cardinals gives them momentum heading into this matchup. With the Cardinals struggling to capitalize on their opportunities as underdogs, the Tigers' moneyline at -105 offers solid value. Detroit's offense has been more consistent in this series, and they should have the edge at home.

Top Player Prop Picks

1. Over 1.5 Total Bases for Spencer Torkelson (+120)

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Spencer Torkelson has been a key contributor for the Tigers, and his ability to hit for extra bases makes this prop appealing. He has been seeing the ball well in recent games, and against a Cardinals pitching staff that has struggled at times, Torkelson is a strong candidate to exceed this line.

2. Over 5.5 Strikeouts for Matthew Boyd (-110)

Matthew Boyd has been a reliable strikeout pitcher for the Tigers, and the Cardinals' lineup has shown vulnerability to strikeouts in recent games. Boyd's ability to mix his pitches effectively should allow him to hit this mark.

3. Over 0.5 RBIs for Nolan Arenado (+140)

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Nolan Arenado remains a consistent offensive threat for the Cardinals. With runners likely to be on base, Arenado's ability to drive in runs makes this prop a strong play, especially at favorable odds.

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