Cleveland Guardians @ Baltimore Orioles Player Props, Picks and Predictions - 4/16/2025 6:35 PM EDT

We have your Cleveland Guardians @ Baltimore Orioles prop betting and game preview needs covered as the Baltimore Orioles hit the road to face the Cleveland Guardians.

Cleveland Guardians @ Baltimore Orioles Pick

Best Moneyline Odds: Cleveland Guardians (-115) at Baltimore Orioles (-105).
Best Total Odds: Over 9 (-115) / Under 9 (-105).

Game Info

Date: April 16, 2025
Time: 6:35 PM EDT
Location: Progressive Field, Cleveland, OH
TV: -

Cleveland Guardians @ Baltimore Orioles Preview

The Cleveland Guardians and Baltimore Orioles meet for the second game of their series after the Guardians secured a 6-3 victory in the opener. Cleveland enters this matchup with an 8-7 record, while Baltimore sits at 6-9. The Guardians will rely on Gavin Williams (1-0, 3.46 ERA) to continue their momentum, while the Orioles counter with Dean Kremer (1-2, 8.16 ERA), who has struggled early this season. Cleveland’s offense has been consistent, while Baltimore will look to bounce back and capitalize on their opportunities at the plate.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on April 15, 2025, the Cleveland Guardians defeated the Baltimore Orioles 6-3. Historically, the Guardians have had the upper hand in this series, winning key games with strong pitching performances and timely hitting. The Orioles, however, have shown flashes of offensive potential, making this an intriguing matchup.

Pick: Cleveland Guardians Moneyline (-115)

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The Guardians are the pick here, given their recent form and the pitching advantage with Gavin Williams on the mound. Williams has been solid with a 3.46 ERA, while Dean Kremer’s struggles (8.16 ERA) make it difficult to trust Baltimore in this spot. Cleveland’s offense has also been more reliable, giving them the edge in this matchup.

Top Player Prop Picks

1. Gavin Williams Over 6.5 Strikeouts

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Williams has been a strikeout machine early in the season, and facing a Baltimore lineup that has struggled against quality pitching, he is poised to rack up strikeouts. Look for him to exceed this line.

2. José Ramírez Over 1.5 Total Bases

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Ramírez has been a consistent force in the Guardians’ lineup and is coming off a strong performance in the series opener. With Kremer’s struggles, Ramírez should have opportunities to deliver extra-base hits.

3. Anthony Santander Over 0.5 Home Runs

Santander remains a key power threat for the Orioles. Despite Baltimore’s struggles, he has the ability to take advantage of any mistakes from Williams and go deep in this game.

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