Cleveland Guardians @ Baltimore Orioles Player Props, Picks and Predictions - 4/15/2025 7:05 PM EDT

We have your Cleveland Guardians @ Baltimore Orioles prop betting and game preview needs covered as the Baltimore Orioles hit the road to face the Cleveland Guardians.

Cleveland Guardians @ Baltimore Orioles Pick

Best Moneyline Odds: Baltimore Orioles -145, Cleveland Guardians +120.
Best Total Odds: Over/Under 8.5 runs (-115 on the over, -105 on the under).

Game Info

Date: April 15, 2025
Time: 7:05 PM EDT
Location: Progressive Field, Cleveland, Ohio
TV: -

Cleveland Guardians @ Baltimore Orioles Preview

The Baltimore Orioles and Cleveland Guardians square off in what promises to be an intriguing matchup. The Orioles come into this game as slight favorites, boasting a moneyline of -145. Baltimore has struggled recently, going 2-3 in their last five games, and they are 1-4 against the spread in that span. Meanwhile, the Guardians are looking to capitalize on their underdog status (+120 moneyline) and turn the tide in their favor.

Both teams have shown flashes of brilliance this season, but consistency has been an issue. The Orioles' offense has been potent at times, but their pitching staff has struggled to keep opponents in check. On the other hand, the Guardians have relied on their pitching to stay competitive, but their offense has been inconsistent. With a total set at 8.5 runs, this game could hinge on which team can execute better in key moments.

Historic Head-to-Head Stats and Analysis

Historically, the Orioles have had the upper hand in this matchup. Out of 438 games played between these two teams, Baltimore has won 246, while Cleveland has secured 192 victories. This historical edge could play a psychological role as the Orioles look to maintain their dominance over the Guardians.

Pick: Baltimore Orioles Moneyline (-145)

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The Orioles are the pick here on the moneyline. Despite their recent struggles, they have a stronger overall roster and a historical edge in this matchup. Their offense has the potential to exploit Cleveland's pitching, and with the Guardians' inconsistent offense, Baltimore should have the upper hand. The -145 odds provide decent value for a team with a favorable matchup.

Top Player Prop Picks

1. Over 1.5 Total Bases for Gunnar Henderson (+120)

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Gunnar Henderson has been a key contributor for the Orioles, and his ability to hit for extra bases makes this prop appealing. With Cleveland's pitching staff struggling to contain left-handed hitters, Henderson could capitalize and exceed this line.

2. Over 5.5 Strikeouts for Shane Bieber (-110)

Shane Bieber has been a strikeout machine for the Guardians, and facing a Baltimore lineup that has been prone to strikeouts, this prop offers solid value. Bieber's ability to mix his pitches effectively should allow him to hit this mark.

3. Over 0.5 Home Runs for Anthony Santander (+300)

Anthony Santander has been one of Baltimore's most consistent power hitters. With Progressive Field being a hitter-friendly park, Santander has a good chance to go deep in this game, especially against a right-handed pitcher.

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