Cleveland Guardians @ Washington Nationals Player Props, Picks and Predictions - 5/6/2025 3:35 PM EDT

We have your Cleveland Guardians @ Washington Nationals prop betting and game preview needs covered as the Washington Nationals hit the road to face the Cleveland Guardians.

Cleveland Guardians @ Washington Nationals Pick

Best Moneyline Odds: Cleveland Guardians -115, Washington Nationals -105
Best Spread Odds: Cleveland Guardians -1.5 (+135), Washington Nationals +1.5 (-181)
Best Total Odds: Over 9 (-115), Under 9 (-105)

Game Info

Date: May 6, 2025
Time: 3:35 PM EDT
Location: Progressive Field, Cleveland, Ohio
TV: -

Cleveland Guardians @ Washington Nationals Preview

The Cleveland Guardians and Washington Nationals square off in an interleague matchup at Progressive Field. The Guardians have been strong as moneyline favorites this season, boasting a 10-3 record in such situations. Meanwhile, the Nationals have struggled as underdogs, with a 12-16 record in games where they were not favored. Cleveland's pitching staff has been a key factor in their success, while Washington's offense has been inconsistent, making this an intriguing matchup to watch.

Historic Head-to-Head Stats and Analysis

In their last 10 head-to-head matchups, the Cleveland Guardians have won 7 games, while the Washington Nationals have taken 3. The Guardians have outscored the Nationals by a combined margin of 45-32 in these contests. Cleveland has also been dominant at home, winning 4 of the last 5 meetings at Progressive Field. These trends suggest a slight edge for the Guardians in this matchup.

Pick: Cleveland Guardians Moneyline (-115)

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The Guardians' strong record as moneyline favorites, combined with their home-field advantage and superior pitching, makes them the safer pick in this matchup. Washington's struggles as underdogs further solidify this choice. Expect Cleveland to control the game and secure the win.

Top Player Prop Picks

1. Over 1.5 Total Bases - José Ramírez

José Ramírez has been a consistent offensive force for the Guardians, and he thrives in matchups against right-handed pitching. With his ability to hit for both power and average, Ramírez is a strong candidate to exceed 1.5 total bases in this game.

2. Over 5.5 Strikeouts - Cleveland Starting Pitcher

The Guardians' starting pitcher has been effective at generating strikeouts, especially against teams with high strikeout rates like the Nationals. Look for him to surpass 5.5 strikeouts in this matchup.

3. Over 0.5 RBIs - Josh Bell

Josh Bell has been a key run producer for the Guardians, and with runners likely to be on base against a shaky Nationals pitching staff, Bell has a good chance to drive in at least one run.

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