Chicago Cubs @ St. Louis Cardinals Player Props, Picks and Predictions - 6/25/2025 7:45 PM EDT

We have your Chicago Cubs @ St. Louis Cardinals prop betting and game preview needs covered as the Chicago Cubs hit the road to face the St. Louis Cardinals.

Chicago Cubs @ St. Louis Cardinals Pick

Best Moneyline Odds: Chicago Cubs -116, St. Louis Cardinals +115.
Best Total Odds: Over/Under 9.0 runs (-110).

Game Info

Date: June 25, 2025
Time: 7:45 PM EDT
Location: Busch Stadium, St. Louis, Missouri
TV: -

Chicago Cubs @ St. Louis Cardinals Preview

The Chicago Cubs and St. Louis Cardinals continue their NL Central rivalry in the second game of this series. The Cardinals edged out the Cubs in a thrilling 8-7 victory on June 24, showcasing their offensive firepower. Both teams are battling for positioning in the division, and this matchup promises to be another high-scoring affair with the total set at 9.0 runs. The Cubs have been strong as moneyline favorites this season, winning 67.3% of such games, while the Cardinals have been competitive as underdogs, going 23-20 in those situations.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on June 24, 2025, the Cardinals defeated the Cubs 8-7. The Cubs entered as slight favorites (-116 moneyline), but the Cardinals capitalized on their home-field advantage. The total for that game was set at 8.5 runs, and the over hit comfortably. This rivalry has been closely contested, with both teams trading wins in recent meetings.

Pick: Chicago Cubs Moneyline (-116)

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The Cubs have been reliable as moneyline favorites this season, boasting a 67.3% win rate in such games. Despite their narrow loss in the series opener, their overall consistency and ability to bounce back make them a strong pick to even the series. The Cardinals have been solid as underdogs, but the Cubs' offensive depth and pitching edge should give them the upper hand in this matchup.

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