Here is the Pickwatch BetSmart Preview for the Buffalo Bills vs. Denver Broncos game in the Divisional Round of the NFL Playoffs.

Buffalo Bills vs. Denver Broncos Game Info

Date: Saturday, January 17, 2025
Time: 4:30 PM ET
Location: Empower Field at Mile High — Denver, Colorado
TV: CBS

Bills vs. Broncos Betting Odds

Point Spread
- Bills +1.5 (-120)
- Broncos -1.5 (-102)
Moneyline
- Bills +100
- Broncos -120
Total
- Over/Under 45.5

Thinking about betting on the Underdog? Be sure to check out our Upset Watch column before you decide!

Season Betting Records

Moneyline
- Bills: 13-5
- Broncos: 14-3
Against the Spread
- Bills: 9-9
- Broncos: 7-9-1
Totals (Over-Under)
- Bills: 9-8-1
- Broncos: 7-10

Buffalo Bills (13-5) @ Denver Broncos (14-3) Preview

Buffalo enters the Divisional Round with one of the league’s most explosive and battle-tested offenses, particularly in cold-weather environments. The Bills thrive when they can play fast early, stress defenses vertically, and force opponents into pass-heavy game scripts.

Denver comes in as a defense-driven team that relies on structure, discipline, and limiting big plays. Their path to staying competitive hinges on slowing Buffalo’s early tempo and forcing long, mistake-free drives. Offensively, the Broncos will need efficiency rather than explosiveness, leaning on ball control and short-area passing to keep Josh Allen off the field.

Weather is expected to be sunny but cold in the low 30s with light wind, which generally favors Buffalo’s experience and physicality. Injuries to monitor include Buffalo managing depth along the defensive line and in the secondary (Damar Hamlin, Questionable), while Denver enters with concerns along the offensive line and at linebacker. If Buffalo controls early downs and avoids turnovers, they are well positioned to advance.

This game sets up as a trench-and-tempo fight: Buffalo wants to lean on the run (and keep Josh Allen clean), while Denver’s pass rush is the headline matchup that can wreck drives and flip field position. The small spread (-1.5) suggest this will be a close battle deep into the 4th quarter, and with how competitive the Wild Card Weekend games were, there's a good chance it continues this weekend.

Bills/Broncos Head-to-Head (H2H) Stats and Analysis

The Buffalo Bills lead the all-time series 24-17-1 against the Denver Broncos. Here are the last 5 meetings:

Buffalo Bills 31, Denver Broncos 7 — January 12, 2025 (Playoffs)
Denver Broncos 24, Buffalo Bills 22 — November 13, 2023
Buffalo Bills 48, Denver Broncos 19 — December 19, 2020
Buffalo Bills 20, Denver Broncos 3 — November 24, 2019
Buffalo Bills 26, Denver Broncos 16 — September 24, 2017

BetSmart Betting Rundown

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NOTE: All available bets are as of time of publication. Odds and lines change often, so be sure to check each subsequent Pickwatch betting tool for the latest numbers.

Arbitrage

Our Arbitrage Betting Tool is currently identifying 4 arbitrage betting opportunities for guaranteed profit. Odds and lines change frequently, however, so be sure to check back often leading up to kickoff.

Middles

Our Middle Betting Tool is currently identifying 33 middle betting opportunities.

Positive EV

Our Positive EV Betting Tool is currently identifying 35 different positive expected value wagers, and provided data on the expected value percentrage, and how often the bet has hit in the last 5, 10 and 15 games.

Player Props

Our Prop Finder Tool is currently identifying 461 different player prop bets, and provided data on how often each player has hit the specific prop in the last 5, 10 and 15 games.

Bills vs. Broncos: Expert Picks

Visit our Expert Picks page to view picks and data from over 200 experts to see where the consensus is on the Bills vs. Broncos moneyline, point spread and total points.