Washington Nationals @ San Diego Padres Player Props, Picks and Predictions - 6/25/2025 4:10 PM EDT

We have your Washington Nationals @ San Diego Padres prop betting and game preview needs covered as the Washington Nationals hit the road to face the San Diego Padres.

Washington Nationals @ San Diego Padres Pick

Best Moneyline Odds: Padres -166, Nationals +141.
Best Spread Odds: Padres -1.5 (+247), Nationals +1.5 (-157).
Best Total Odds: Over/Under 8 Runs (-110 for both).

Game Info

Date: June 25, 2025
Time: 4:10 PM EDT
Location: PETCO Park, San Diego, CA
TV: -

Washington Nationals @ San Diego Padres Preview

The San Diego Padres (42-36) host the Washington Nationals (33-46) in the second game of their series at PETCO Park. The Padres secured a narrow 4-3 victory in the first game, showcasing their pitching depth and timely hitting. The Nationals, on the other hand, are looking to bounce back and improve their road record. With the Padres boasting a top-10 pitching staff (3.67 ERA), the Nationals will need to find ways to generate offense against a formidable opponent.

Historic Head-to-Head Stats and Analysis

In their recent matchups, the Padres have had the upper hand, including their 4-3 win on June 24, 2025. Historically, the Padres have performed well at home against the Nationals, leveraging their strong pitching and home-field advantage. The Nationals have struggled in San Diego, with a 3-8 record in their last 11 games against the Padres. This trend highlights the challenge Washington faces in this matchup.

Pick: Padres -1.5 (+247)

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The Padres are the stronger team on paper, with a superior pitching staff and a better overall record. Their ability to control the game at home makes them a solid pick to cover the -1.5 spread. The Nationals' recent struggles, both straight up and against the spread, further support this selection. Backing the Padres to win by at least two runs offers excellent value at +247.

Top Player Prop Picks

1. Ryan Bergert Over 5.5 Strikeouts (+120)

Bergert has been impressive on the mound with a 1.88 ERA. Against a Nationals lineup that has struggled offensively, he is well-positioned to rack up strikeouts. This line offers solid value given his recent form.

3. Lane Thomas Over 0.5 Home Runs (+400)

Lane Thomas has been one of the Nationals' most reliable hitters this season. While the Padres' pitching is strong, Thomas has the power to capitalize on any mistakes. At +400, this is a high-risk, high-reward prop worth considering.

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