St. Louis Cardinals @ Chicago White Sox Player Props, Picks and Predictions - 6/19/2025 2:10 PM EDT

We have your St. Louis Cardinals @ Chicago White Sox prop betting and game preview needs covered as the St. Louis Cardinals hit the road to face the Chicago White Sox.

St. Louis Cardinals @ Chicago White Sox Pick

Best Moneyline Odds: St. Louis Cardinals -146, Chicago White Sox +145.
Best Spread Odds: St. Louis Cardinals -1.5 (+105), Chicago White Sox +1.5 (-125).
Best Total Odds: Over 8.5 (-105), Under 8.5 (-115).

Game Info

Date: June 19, 2025
Time: 2:10 PM EDT
Location: Guaranteed Rate Field, Chicago, IL
TV: -

St. Louis Cardinals @ Chicago White Sox Preview

The St. Louis Cardinals (38-35) are looking to build momentum as they visit the struggling Chicago White Sox (23-50). The Cardinals are coming off a strong offensive performance in their recent games, while the White Sox continue to face challenges both offensively and defensively. Michael McGreevy (1-1, 3.09 ERA) will take the mound for the Cardinals, while Mike Vasil (3-1, 1.99 ERA) will pitch for the White Sox. This matchup pits a solid Cardinals lineup against a White Sox team that has struggled to find consistency this season.

Historic Head-to-Head Stats and Analysis

In their most recent head-to-head matchup on June 17, 2025, the Cardinals dominated the White Sox with a 12-2 victory. The Cardinals were favored in that game with a moneyline of -132 and covered the -1.5 spread. The total for that game was set at 9, and the over hit comfortably. Historically, the Cardinals have had the upper hand in this matchup, showcasing their offensive firepower against the White Sox's pitching struggles.

Pick: St. Louis Cardinals Moneyline (-146)

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The Cardinals are the clear favorites in this matchup, and for good reason. With Michael McGreevy on the mound and a potent offense, they have the tools to exploit the White Sox's weaknesses. The White Sox have struggled to find consistency, and their 23-50 record reflects their ongoing challenges. Backing the Cardinals on the moneyline is the safest play here.

Top Player Prop Picks

1. Michael McGreevy Over 5.5 Strikeouts

McGreevy has been effective in his recent starts, and facing a White Sox lineup that has struggled offensively, he has a strong chance to rack up strikeouts. Look for him to go deep into the game and surpass this line.

2. Brendan Donovan Over 1.5 Total Bases

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Donovan has been a key contributor for the Cardinals, and his recent performance at the plate has been impressive. Against a White Sox pitching staff that has struggled, Donovan is well-positioned to exceed this total bases line.

3. Mike Vasil Under 2.5 Earned Runs

Despite the White Sox's struggles, Vasil has been a bright spot with a 1.99 ERA. He has the ability to limit damage, and this line offers value for bettors expecting a solid outing from him.

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