St. Louis Cardinals @ Chicago White Sox Player Props, Picks and Predictions - 6/17/2025 7:40 PM EDT

We have your St. Louis Cardinals @ Chicago White Sox prop betting and game preview needs covered as the St. Louis Cardinals hit the road to face the Chicago White Sox.

St. Louis Cardinals @ Chicago White Sox Pick

Best Moneyline Odds: Cardinals -150, White Sox +130
Best Spread Odds: Cardinals -1.5 (+110), White Sox +1.5 (-130)
Best Total Odds: Under 8.5 (-110), Over 8.5 (-110)

Game Info

Date: June 17, 2025
Time: 7:40 PM EDT
Location: Guaranteed Rate Field, Chicago, IL
TV: -

St. Louis Cardinals @ Chicago White Sox Preview

The St. Louis Cardinals (37-35) head to Chicago to take on the struggling White Sox (23-49) in what promises to be an intriguing matchup. The Cardinals are coming off a tough stretch, winning just one of their last eight games, while the White Sox have lost five straight. Both teams are looking to turn their fortunes around, with the Cardinals relying on their solid pitching staff and the White Sox hoping for a spark from their offense.

On the mound, the Cardinals will likely send Sonny Gray (7-2, 3.84 ERA) to face Sean Burke (3-7, 4.71 ERA) for the White Sox. Gray has been a reliable arm for St. Louis, while Burke has struggled to find consistency this season. The Cardinals' offense, led by a mix of veteran and young talent, will look to capitalize on Burke's vulnerabilities.

Historic Head-to-Head Stats and Analysis

In their last five meetings, the Cardinals have had the upper hand, winning three of those games. However, the White Sox have managed to keep some of these contests close, particularly at home. The Cardinals' pitching has been a key factor in their success against Chicago, limiting the White Sox to an average of fewer than four runs per game in these matchups.

Pick: Cardinals Moneyline (-150)

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The Cardinals are the clear favorites in this matchup, and for good reason. With Sonny Gray on the mound and the White Sox struggling both offensively and defensively, St. Louis has a significant edge. While the White Sox have the home-field advantage, their recent form and pitching struggles make it difficult to back them in this spot. The Cardinals' moneyline at -150 offers solid value for bettors.

Top Player Prop Picks

1. Sonny Gray Over 6.5 Strikeouts (-110)

Gray has been a strikeout machine this season, and facing a White Sox lineup that has struggled against right-handed pitching, he should have plenty of opportunities to rack up strikeouts. Look for Gray to dominate on the mound and surpass this line.

2. Paul Goldschmidt Over 1.5 Total Bases (+120)

Goldschmidt has been a consistent force in the Cardinals' lineup and has a favorable matchup against Sean Burke. With his ability to hit for both power and average, Goldschmidt is a strong candidate to exceed 1.5 total bases in this game.

3. Luis Robert Jr. Over 0.5 Home Runs (+400)

Despite the White Sox's struggles, Robert Jr. has been a bright spot in their lineup. He has the power to take any pitcher deep, and at +400, this prop offers excellent value for a player with his home run potential.