Seattle Mariners @ Boston Red Sox Player Props, Picks and Predictions - 4/22/2025 6:45 PM EDT

We have your Seattle Mariners @ Boston Red Sox prop betting and game preview needs covered as the Boston Red Sox hit the road to face the Seattle Mariners.

Seattle Mariners @ Boston Red Sox Pick

Best Moneyline Odds: Boston Red Sox -140, Seattle Mariners +115.
Best Total Odds: Over/Under 9 runs (-110).

Game Info

Date: April 22, 2025
Time: 6:45 PM EDT
Location: Fenway Park, Boston, MA
TV: -

Seattle Mariners @ Boston Red Sox Preview

The Boston Red Sox (13-11) host the Seattle Mariners (12-10) in what promises to be an exciting matchup at Fenway Park. The Red Sox are coming off a 4-2 victory over the Chicago White Sox, while the Mariners look to bounce back after a mixed start to their season. Boston has been strong at home, and their offense has been clicking, making them slight favorites in this contest. Meanwhile, the Mariners have shown resilience on the road and will aim to capitalize on any pitching vulnerabilities from the Red Sox.

Historic Head-to-Head Stats and Analysis

In their last 10 meetings, the Boston Red Sox have had the upper hand, winning 6 of those matchups. The Red Sox have also been dominant at Fenway Park, where they have won 4 of their last 5 home games against the Mariners. Historically, these games have leaned towards higher-scoring affairs, with the total going over in 7 of their last 10 meetings.

Pick: Boston Red Sox Moneyline (-140)

The Red Sox have been solid at home and are coming off a strong performance against the White Sox. With their offense firing on all cylinders and a favorable head-to-head record against the Mariners, Boston is the safer pick on the moneyline. The Mariners have struggled to find consistency on the road, which further supports this selection.

Top Player Prop Picks

1. Rafael Devers Over 1.5 Total Bases (+120)

Devers has been a key offensive contributor for the Red Sox, and his power at Fenway Park is undeniable. He has recorded multiple total bases in 3 of his last 5 games, making this a strong value play.

2. Julio Rodríguez Over 0.5 Home Runs (+400)

Rodríguez has been heating up at the plate and has a favorable matchup against Boston's pitching staff. His ability to hit for power makes this a high-upside prop bet.

3. Chris Sale Over 6.5 Strikeouts (-110)

Sale has been dominant in recent starts, averaging 8 strikeouts per game over his last three outings. Facing a Mariners lineup that has been prone to strikeouts, this prop offers solid value.

New customer offers and more lines available at:

Free Picks available for new customers at: