San Francisco Giants @ San Diego Padres Player Props, Picks and Predictions - 4/30/2025 4:10 PM EDT

We have your San Francisco Giants @ San Diego Padres prop betting and game preview needs covered as the San Diego Padres hit the road to face the San Francisco Giants.

San Francisco Giants @ San Diego Padres Pick

Best Moneyline Odds: Padres -135, Giants +115.
Best Spread Odds: Padres -1.5 (+170), Giants +1.5 (-210).
Best Total Odds: Over 7 (-110), Under 7 (-110).

Game Info

Date: April 30, 2025
Time: 4:10 PM EDT
Location: Oracle Park, San Francisco, CA
TV: -

San Francisco Giants @ San Diego Padres Preview

The San Diego Padres and San Francisco Giants face off in the second game of their series at Oracle Park. The Padres took the first game with a 7-4 victory, showcasing their offensive firepower. Both teams are battling for positioning in the NL West, making this matchup critical for momentum. The Padres have been strong as moneyline favorites this season, boasting a 9-3 record when favored at -135 or shorter. Meanwhile, the Giants have been competitive as underdogs, but their pitching staff will need to step up to contain the Padres' bats.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on April 29, 2025, the Padres defeated the Giants 7-4. Historically, the Padres have had the upper hand in recent meetings, leveraging their strong lineup and consistent pitching. The Giants, however, have shown resilience in close games, making this rivalry one to watch closely.

Pick: Padres Moneyline (-135)

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The Padres have been reliable as favorites this season, winning 75% of games when favored at -135 or shorter. Their offense is clicking, as evidenced by their seven-run performance in the previous game. With momentum on their side and a favorable pitching matchup, the Padres are the pick to win outright.

Top Player Prop Picks

1. Manny Machado Over 1.5 Total Bases (+120)

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Manny Machado has been a key contributor for the Padres, and his ability to hit for extra bases makes this prop appealing. He has a strong track record against the Giants' pitching staff and is poised for another big game.

2. Fernando Tatis Jr. Over 0.5 Home Runs (+350)

Fernando Tatis Jr. is always a threat to go deep, and Oracle Park's dimensions could play to his advantage. With his power and recent form, this is a high-value prop to consider.

3. Logan Webb Over 5.5 Strikeouts (-110)

Logan Webb, the Giants' ace, has been a strikeout machine this season. Despite the Padres' potent lineup, Webb's ability to miss bats makes this a solid prop bet.

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