San Francisco Giants @ Pittsburgh Pirates Player Props, Picks and Predictions - 8/6/2025 12:35 PM EDT

We have your San Francisco Giants @ Pittsburgh Pirates prop betting and game preview needs covered as the San Francisco Giants hit the road to face the Pittsburgh Pirates.

San Francisco Giants @ Pittsburgh Pirates Pick

Best Moneyline Odds: San Francisco Giants -145 at Caesars
Best Spread Odds: Pittsburgh Pirates +1.5 (-128) at Fanduel / San Francisco Giants -1.0 (-123) at DraftKings
Best Total Odds: Over 7.5 (-115) at Caesars / Under 8.5 (-130) at ESPN BET

Game Info

Date: 2025-08-06
Time: 12:35 PM EDT
Location: PNC Park, Pittsburgh
TV: -

San Francisco Giants @ Pittsburgh Pirates Preview

The San Francisco Giants (57-57) are set to conclude their three-game series against the Pittsburgh Pirates (49-65) at PNC Park on Wednesday afternoon. The Giants are coming off a dominant 8-1 victory that evened the series, showcasing their offensive potential with every player in the lineup recording a hit. Despite being sellers at the trade deadline, the Giants are fighting to stay in the postseason hunt, currently sitting six games out of the final NL Wild Card spot. Their ace, Robbie Ray (9-5, 2.85 ERA), will take the mound, looking to continue his strong season. Ray is known for his high-velocity fastball and devastating slider, which could pose a significant challenge for the Pirates' lineup, especially against key left-handed bats like Oneil Cruz, who is prone to strikeouts.

On the other side, the Pittsburgh Pirates will send Andrew Heaney (5-9, 4.89 ERA) to the mound. Heaney is looking for a bounce-back performance after a disastrous last outing where he allowed four runs in just 3.1 innings, contributing to a historic comeback by the Colorado Rockies. While the Pirates have shown resilience as underdogs recently, with a 7-3 record in their last ten games, their overall offensive struggles could make it difficult to generate sustained rallies against a pitcher of Ray's caliber. The Giants' lineup features several right-handed power threats who have historically performed well against left-handed pitching, which could exploit Heaney's susceptibility to the home run ball and wavering command.

The Pirates are dealing with several injuries, including Chase Shugart (15-Day-IL), Justin Lawrence (60-Day-IL), Tim Mayza (60-Day-IL), and Endy Rodríguez (60-Day-IL). Day-to-day concerns include Jack Brannigan, Anthony Solometo, Malcom Nuñez, and Abrahan Gutierrez. The Giants also have some players on the injury list, with Wilmer Flores (Day-to-Day Hamstring), Tom Murphy (Out Back), Erik Miller (Out Elbow), and Landen Roupp (Out Elbow).

Historic Head-to-Head Stats and Analysis

The recent head-to-head history between the San Francisco Giants and Pittsburgh Pirates shows some interesting trends. In their last three games this season, the Giants hold a 2-1 record against the Pirates on the run line. Looking at the total runs, the Over has hit in six of the last eight head-to-head meetings between these two clubs. However, a conflicting trend indicates that three of the past four meetings at PNC Park have ended with fewer than five combined runs, suggesting that this venue tends to favor pitching and defensive efficiency, especially later in the summer. Both teams have historically struggled to produce high-scoring games when matched up at PNC Park.

Pick: San Francisco Giants Moneyline

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The San Francisco Giants moneyline at -145 via Caesars is the strongest pick for this matchup. The Giants hold a significant advantage in the pitching matchup with Robbie Ray on the mound. Ray boasts a strong 2.85 ERA and has been a model of consistency, while Pirates starter Andrew Heaney has struggled recently, with his ERA ballooning to 4.89. The Giants' offense has shown signs of life, particularly in their recent 8-1 victory where every player recorded a hit, and they possess right-handed power threats that can exploit Heaney's vulnerabilities. While there's some conflicting head-to-head data regarding the total runs at PNC Park, the overall pitching mismatch and the Giants' motivation to stay in the Wild Card race make them the clear favorites. Sharp money also leans heavily towards the Giants, with a 58.07% sharp win percentage on their moneyline.

Top Player Prop Picks

Casey Schmitt (San Francisco Giants) - Over 0.5 Hits

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Casey Schmitt has been a consistent hitter for the Giants, making the Over 0.5 Hits prop an attractive play at -220 odds on Fanduel. He has hit the over in 100% of his last five games and 90% of his last ten games, demonstrating excellent recent form. Furthermore, in three games against the Pittsburgh Pirates this season, Schmitt has hit the over on this prop 100% of the time, averaging 1.0 hit per game. When playing on the road in 2025, he has hit the over 62.96% of the time, averaging 0.78 hits. His season average of 0.8 hits also supports hitting this line.

Tommy Pham (Pittsburgh Pirates) - Over 0.5 Hits

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Tommy Pham is a strong candidate for the Over 0.5 Hits prop at -165 odds on BetMGM. Pham has been hitting well recently, going over this line in 80% of his last five games and 90% of his last ten games. His performance against the Giants this season is particularly noteworthy, as he has hit the over 75% of the time in four games, averaging 1.5 hits. Playing at home in 2025, Pham has hit the over 55.81% of the time, with an average of 0.81 hits. His season average of 0.86 hits further supports this pick.

Jung Hoo Lee (San Francisco Giants) - Over 1.5 Hits + Runs + RBIs

Jung Hoo Lee presents a compelling case for the Over 1.5 Hits + Runs + RBIs prop at -120 odds on DraftKings. Lee has been on a hot streak, hitting the over in 100% of his last five games with an average of 3.4 combined Hits + Runs + RBIs. Over his last ten games, he has hit the over 70% of the time, averaging 2.3. While his season hit rate for this prop is 50.93% (1.91 average), his recent form and performance on the road are encouraging. In 2025 road games, Lee has hit the over 53.57% of the time, averaging 2.09 combined Hits + Runs + RBIs. Against the Pirates this season, he has hit the over 60% of the time in five games, averaging 1.4.

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