San Francisco Giants @ Chicago Cubs Player Props, Picks and Predictions - 5/7/2025 2:20 PM EDT

We have your San Francisco Giants @ Chicago Cubs prop betting and game preview needs covered as the Chicago Cubs hit the road to face the San Francisco Giants.

San Francisco Giants @ Chicago Cubs Pick

Best Moneyline Odds: Chicago Cubs -130, San Francisco Giants +110.
Best Spread Odds: Cubs -1.5 (+150).
Best Total Odds: Over/Under 8 runs (-110).

Game Info

Date: May 7, 2025
Time: 2:20 PM EDT
Location: Wrigley Field, Chicago, IL
TV: -

San Francisco Giants @ Chicago Cubs Preview

The San Francisco Giants and Chicago Cubs meet for the second game of their series at Wrigley Field. The Giants dominated the Cubs in the first game, securing a 14-5 victory. San Francisco's offense exploded, showcasing their ability to capitalize on scoring opportunities. Meanwhile, the Cubs will look to bounce back and rely on their home-field advantage to even the series. Both teams are in the thick of their respective division races, making this matchup critical for momentum.

Historic Head-to-Head Stats and Analysis

In their last 10 meetings, the Giants and Cubs have been evenly matched, with each team winning five games. However, the Giants have had the upper hand recently, winning three of the last four matchups, including the 14-5 blowout in the series opener. The Cubs have struggled to contain the Giants' offense, allowing an average of 7.5 runs per game in their last four meetings.

Pick: Total Over 8 Runs (-110)

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Given the offensive explosion by the Giants in the first game and the Cubs' ability to score at home, the over on 8 runs is an appealing pick. The Giants' bats are hot, and the Cubs will likely respond with a stronger offensive showing. Both teams have shown tendencies for high-scoring games in recent matchups, making the over a solid play.

Top Player Prop Picks

1. Player to Hit a Home Run: Joc Pederson (+350)

Joc Pederson has been a key contributor for the Giants, and his power at the plate makes him a strong candidate to go deep. With the Cubs' pitching staff struggling to contain the Giants' lineup, Pederson's odds to hit a home run are worth considering.

2. Total Strikeouts: Justin Steele Over 5.5 (+120)

Justin Steele, the Cubs' starting pitcher, has been effective at generating strikeouts this season. Facing a Giants lineup that can be aggressive at the plate, Steele has a good chance to surpass the 5.5 strikeout mark.

3. Total Hits + Runs + RBIs: Thairo Estrada Over 2.5 (+110)

Thairo Estrada has been a consistent performer for the Giants, contributing across multiple categories. With the Giants' offense firing on all cylinders, Estrada is poised to exceed 2.5 combined hits, runs, and RBIs in this game.

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