San Francisco Giants @ Chicago Cubs Player Props, Picks and Predictions - 5/6/2025 7:40 PM EDT

We have your San Francisco Giants @ Chicago Cubs prop betting and game preview needs covered as the Chicago Cubs host the San Francisco Giants in what promises to be an exciting matchup.

San Francisco Giants @ Chicago Cubs Pick

Best Moneyline Odds: Chicago Cubs -148, San Francisco Giants +126.
Best Total Odds: Over/Under 8 (-).

Game Info

Date: May 6, 2025
Time: 7:40 PM EDT
Location: Wrigley Field, Chicago, IL
TV: -

San Francisco Giants @ Chicago Cubs Preview

The Chicago Cubs come into this game as the favorites after a dominant 9-2 victory over the Giants in the series opener. The Cubs have been solid at home and are looking to build on their recent momentum. Meanwhile, the Giants are struggling to find consistency, particularly on the road, and will need a strong performance to even the series.

Historic Head-to-Head Stats and Analysis

In their last matchup on May 5, 2025, the Cubs defeated the Giants 9-2, showcasing their offensive firepower. Over their last 10 meetings, the Cubs have had the upper hand, winning 6 of those games. The Giants have struggled to keep up offensively in these matchups, often falling short in run production.

Pick: Chicago Cubs Moneyline (-148)

widget-odds-mlb-su-10648-SF-CHC

The Cubs are the clear favorites in this matchup, and for good reason. They have been strong at home and are coming off a convincing win against the Giants. With their offense clicking and the Giants struggling on the road, the Cubs moneyline is the most logical pick for this game.

Top Player Prop Picks

1. Cody Bellinger Over 0.5 Home Runs (+400)

Bellinger has been a key offensive contributor for the Cubs and has shown the ability to go deep, especially at Wrigley Field. With the Giants' pitching staff struggling, this is a high-value prop to consider.

2. Marcus Stroman Over 5.5 Strikeouts (-110)

Stroman has been a reliable arm for the Cubs and is coming off a strong performance. Facing a Giants lineup that has been prone to strikeouts, this prop has solid potential.

3. Joc Pederson Over 1.5 Total Bases (+120)

Pederson remains a key offensive piece for the Giants and has the ability to rack up extra-base hits. He will be a focal point of the Giants' offense as they look to bounce back.

New customer offers and more lines available at:

Free Picks available for new customers at: