San Francisco Giants @ Chicago Cubs Player Props, Picks and Predictions - 5/5/2025 7:40 PM EDT

We have your San Francisco Giants @ Chicago Cubs prop betting and game preview needs covered as the Chicago Cubs hit the road to face the San Francisco Giants.

San Francisco Giants @ Chicago Cubs Pick

Best Moneyline Odds: Chicago Cubs -145, San Francisco Giants +125.
Best Total Odds: Over 7.5 (-115), Under 7.5 (-105).

Game Info

Date: May 5, 2025
Time: 7:40 PM EDT
Location: Oracle Park, San Francisco, CA
TV: -

San Francisco Giants @ Chicago Cubs Preview

The Chicago Cubs and San Francisco Giants square off in what promises to be an exciting matchup. The Cubs are coming off a shutout loss to the Milwaukee Brewers, while the Giants are riding high after a dominant 9-3 victory over the Colorado Rockies. Both teams are looking to gain momentum as they continue their respective campaigns. The Cubs have been solid as moneyline favorites this season, boasting a 13-6 record in such situations. Meanwhile, the Giants have been strong at home, with a 14-7 record when favored on the moneyline. This game could hinge on pitching matchups and timely hitting, as both teams have shown flashes of brilliance in recent games.

Historic Head-to-Head Stats and Analysis

In their last 10 head-to-head matchups, the Giants and Cubs have been evenly matched, with each team securing five wins. The total has gone OVER in four of the last six meetings between these two teams, indicating a trend toward higher-scoring games. Additionally, the Cubs have struggled on the road recently, while the Giants have been strong at home, which could play a pivotal role in this contest.

Pick: Chicago Cubs Moneyline (-145)

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The Cubs have been reliable as moneyline favorites this season, and their recent form suggests they can bounce back from their loss to the Brewers. With a solid pitching rotation and a lineup capable of producing runs, the Cubs are well-positioned to secure a win in this matchup. The Giants' home-field advantage is a factor, but the Cubs' consistency as favorites makes them the safer pick.

Top Player Prop Picks

1. Willy Adames Over 0.5 Home Runs

Willy Adames has been on fire recently, hitting two home runs in his last game. His power at the plate makes this a strong prop bet, especially against a Giants pitching staff that has been vulnerable to the long ball in recent games.

2. Cubs Total Runs Over 4.5

The Cubs' offense has been productive, and they will look to capitalize on the Giants' pitching. With players like Adames leading the charge, the Cubs have the potential to exceed this total.

3. Giants' Starting Pitcher Under 5.5 Strikeouts

The Cubs' lineup has been disciplined at the plate, and their ability to make contact could limit the strikeout potential of the Giants' starting pitcher. This makes the under on strikeouts a favorable play.

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