San Diego Padres @ Toronto Blue Jays Player Props, Picks and Predictions - 5/22/2025 1:07 PM EDT

We have your San Diego Padres @ Toronto Blue Jays prop betting and game preview needs covered as the Toronto Blue Jays hit the road to face the San Diego Padres.

San Diego Padres @ Toronto Blue Jays Pick

Best Moneyline Odds: Toronto Blue Jays -182, San Diego Padres +135.
Best Spread Odds: Toronto Blue Jays -1.5 (+125), San Diego Padres +1.5 (-150).
Best Total Odds: Over 8.5 (-120), Under 8.5 (+100).

Game Info

Date: May 22, 2025
Time: 1:07 PM EDT
Location: Rogers Centre, Toronto, Canada
TV: -

San Diego Padres @ Toronto Blue Jays Preview

The Toronto Blue Jays are coming off a dominant 14-0 victory over the San Diego Padres in the previous game of this series. The Blue Jays' offense exploded, while the Padres struggled to find any rhythm at the plate. Toronto will look to carry this momentum into the series finale, while San Diego aims to snap a five-game losing streak and end a run of 32 scoreless at-bats with runners in scoring position. This matchup is critical for both teams as they look to solidify their standings in their respective divisions.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on May 21, 2025, the Toronto Blue Jays routed the San Diego Padres 14-0. Historically, the Blue Jays have had the upper hand in recent meetings, leveraging their strong offensive capabilities. The Padres, on the other hand, have struggled to capitalize on scoring opportunities, as evidenced by their current slump with runners in scoring position.

Pick: Toronto Blue Jays Moneyline (-182)

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The Blue Jays are the clear favorites in this matchup, especially after their dominant performance in the previous game. Their offense is firing on all cylinders, and the Padres' inability to produce runs makes Toronto the safer pick. While the moneyline odds of -182 may not offer significant value, the Blue Jays' recent form and home-field advantage make them the logical choice.

Top Player Prop Picks

1. Vladimir Guerrero Jr. Over 1.5 Total Bases (+110)

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Guerrero Jr. has been a key contributor to the Blue Jays' offense and is coming off a strong performance in the previous game. With the Padres' pitching staff struggling, Guerrero Jr. is well-positioned to exceed this line.

2. Fernando Tatis Jr. Over 0.5 Home Runs (+400)

Despite the Padres' offensive struggles, Tatis Jr. remains a threat at the plate. If San Diego is to break out of their slump, Tatis Jr. will likely play a pivotal role, making this a high-upside prop bet.

3. Kevin Gausman Over 6.5 Strikeouts (-115)

Gausman has been a strikeout machine this season and faces a Padres lineup that has been inconsistent at the plate. Expect Gausman to take advantage of San Diego's struggles and rack up the strikeouts.

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