San Diego Padres @ Toronto Blue Jays Player Props, Picks and Predictions - 5/21/2025 7:07 PM EDT

We have your San Diego Padres @ Toronto Blue Jays prop betting and game preview needs covered as the Toronto Blue Jays hit the road to face the San Diego Padres.

San Diego Padres @ Toronto Blue Jays Pick

Best Moneyline Odds: Toronto Blue Jays -148, San Diego Padres +126 (Bet Now).
Best Spread Odds: San Diego Padres +1.5 (Bet Now).
Best Total Odds: Over/Under 8.5 runs (Bet Now).

Game Info

Date: May 21, 2025
Time: 7:07 PM EDT
Location: Rogers Centre, Toronto, Canada
TV: -

San Diego Padres @ Toronto Blue Jays Preview

The Toronto Blue Jays and San Diego Padres meet for the second game of their series. The Blue Jays secured a 3-0 victory in the opener, showcasing strong pitching and timely hitting. Toronto, sitting at 23-24, is looking to build momentum and climb back to .500, while the Padres, at 27-19, aim to bounce back and maintain their strong start to the season. Both teams feature potent lineups, but pitching will likely dictate the outcome of this matchup.

Historic Head-to-Head Stats and Analysis

In their last five meetings, the Toronto Blue Jays have dominated the San Diego Padres, winning four of those matchups. The most recent game on May 20, 2025, saw the Blue Jays shut out the Padres 3-0, with Toronto's pitching staff stifling San Diego's offense. Historically, the Blue Jays have had the upper hand in this interleague rivalry, leveraging their home-field advantage at Rogers Centre.

Pick: Toronto Blue Jays Moneyline (-148)

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The Blue Jays are the pick on the moneyline due to their recent dominance over the Padres and their strong performance at home. Toronto's pitching staff has been effective in containing San Diego's lineup, as evidenced by the shutout in the series opener. Additionally, the Padres have struggled recently, going 1-4 in their last five games. Backing the Blue Jays to secure another win at home is a solid play.

Top Player Prop Picks

1. Vladimir Guerrero Jr. Over 1.5 Total Bases (+120)

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Guerrero Jr. has been a consistent force in the Blue Jays' lineup and thrives at Rogers Centre. With his ability to hit for power and average, he is a strong candidate to surpass 1.5 total bases in this matchup.

2. Fernando Tatis Jr. Over 0.5 Home Runs (+350)

Tatis Jr. remains a threat at the plate despite the Padres' recent struggles. His power and ability to capitalize on mistakes make him a solid pick to go deep in this game.

3. Kevin Gausman Over 6.5 Strikeouts (-110)

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Gausman has been a strikeout machine this season and is coming off a strong performance. Facing a Padres lineup that has shown vulnerability to strikeouts, Gausman is well-positioned to exceed 6.5 strikeouts in this contest.

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