San Diego Padres @ St. Louis Cardinals Player Props, Picks and Predictions - 7/24/2025 7:45 PM EDT

We have your San Diego Padres @ St. Louis Cardinals prop betting and game preview needs covered as the San Diego Padres hit the road to face the St. Louis Cardinals.

San Diego Padres @ St. Louis Cardinals Pick

Best Moneyline Odds: Padres +118 / Cardinals -136
Best Spread Odds: Cardinals -1.5 / Padres +1.5
Best Total Odds: Over 8.0 Runs / Under 8.0 Runs

Game Info

Date: July 24, 2025
Time: 7:45 PM EDT
Location: Busch Stadium, St. Louis, Missouri
TV: -

San Diego Padres @ St. Louis Cardinals Preview

The San Diego Padres (55-47) travel to Busch Stadium to take on the St. Louis Cardinals (52-51) in what promises to be a competitive matchup. Both teams are looking to bounce back after recent losses; the Padres fell 3-2 to the Miami Marlins yesterday, while the Cardinals were shut out 6-0 by the Colorado Rockies. The Cardinals have shown a strong performance when favored on the moneyline, winning 54.2% of those games this season, including a 13-7 record (65% win rate) in specific favored scenarios. The Padres enter this game as slight underdogs, according to current betting lines.

Historic Head-to-Head Stats and Analysis

No specific historic head-to-head statistics between the San Diego Padres and St. Louis Cardinals were available in the provided research to analyze their past matchups.

Pick: St. Louis Cardinals Moneyline

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The St. Louis Cardinals, playing at home, present a compelling moneyline pick in this contest. Their season record of 52-51, while close to .500, is bolstered by a strong performance when they are favored, winning 65% of such games in certain scenarios and 54.2% overall. With Sonny Gray, who has recorded a win in each of his last three starts, expected to take the mound, the Cardinals have a solid pitching advantage. The Padres, coming off a close loss, face a Cardinals team that performs well in their favored role at home. The current moneyline odds of Cardinals -136 reflect their favored status, and their historical performance in similar situations suggests a good chance to secure the win.

Top Player Prop Picks

Willson Contreras to Record a Double

Willson Contreras has been a consistent extra-base hit threat for the Cardinals, especially when the team is favored. He has recorded a double in five of the Cardinals' last six games when they were listed as favorites. This strong recent trend indicates he's seeing the ball well and finding gaps, making him a prime candidate to hit another double in this matchup.

Manny Machado to Hit a Home Run

Manny Machado is a key power bat for the San Diego Padres, and he's been highlighted as a player to watch for a home run in this game. While it's noted as a "negative correlation play" with the Under 8 total, Machado's ability to change the game with one swing makes this an intriguing prop. If he connects, it could significantly impact the game's scoring.

Sonny Gray to Record a Win

St. Louis Cardinals pitcher Sonny Gray has been in excellent form, having recorded a win in each of his three previous starts. This consistent winning performance suggests he's pitching effectively and receiving sufficient run support from the Cardinals' offense. Facing a Padres team that recently struggled to score, Gray is in a good position to extend his winning streak and secure another victory for the Cardinals.

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