San Diego Padres @ Seattle Mariners Player Props, Picks and Predictions - 8/27/2025 4:10 PM EDT

We have your San Diego Padres @ Seattle Mariners prop betting and game preview needs covered as the San Diego Padres hit the road to face the Seattle Mariners.

San Diego Padres @ Seattle Mariners Pick

Best Moneyline Odds: Seattle Mariners -135 on BetMGM / San Diego Padres +125 on ESPN BET
Best Spread Odds: Seattle Mariners -1.5 (+150)
Best Total Odds: Over 7.5 (-120) on ESPN BET / Under 8.0 (-117) on DraftKings

Game Info

Date: 2025-08-27
Time: 4:10 PM EDT
Location: T-Mobile Park, Seattle
TV: ESPN+

San Diego Padres @ Seattle Mariners Preview

The San Diego Padres (75-58) travel to T-Mobile Park to take on the Seattle Mariners (71-62) in what promises to be a compelling MLB matchup. The Padres enter this contest with strong momentum, having secured 6 wins in their last 10 games, showcasing a robust offense averaging 5 runs per game and a solid defense allowing around 4 runs per game. They are coming off a narrow 7-6 victory over the Mariners yesterday, which should boost their confidence on the road.

Conversely, the Seattle Mariners have been in a bit of a slump, managing only 3 wins in their last 10 outings. Their offense averages 4.7 runs per game, but their pitching has been a concern, giving up approximately 6 runs per game. Despite their recent struggles, the Mariners will look to leverage their home-field advantage at T-Mobile Park, a venue known for its artificial turf. The pitching matchup features Yu Darvish for the Padres and Bryan Woo for the Mariners. T-Mobile Park generally plays as a pitcher-friendly park, ranking 28th in MLB for park factor from 2023-2025.

Historic Head-to-Head Stats and Analysis

The head-to-head history between these two teams leans in favor of the Seattle Mariners. In their last 11 meetings, the Mariners hold a dominant 9-2 record against the Padres. When playing at home in Seattle, the Mariners have also had the upper hand, winning 4 of their last 6 encounters against San Diego. Overall, in recent years, Seattle has claimed 32 victories in head-to-head matchups, with 14 of those coming at home, compared to the Padres' 27 wins, 13 of which were on the road.

Their most recent game, played yesterday, saw the Padres edge out a 7-6 victory. Historically, these matchups tend to be higher-scoring affairs, with an average of over 6 runs combined. The Mariners typically score more than 3.5 runs in their head-to-head games against the Padres, indicating their lineup's potential to produce against San Diego's pitching.

Pick: Over 7.5 Total Runs

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Despite T-Mobile Park's reputation as a pitcher-friendly venue, the recent offensive output and historical trends between these two teams point towards a higher-scoring game. The Padres and Mariners combined for 13 runs in their last game, a 7-6 Padres win. This recent performance aligns with their historical head-to-head average of over 6 runs. The Padres' offense has been hot, averaging 5 runs per game over their last 10, while the Mariners, despite their struggles, still average 4.7 runs per game and have shown a tendency for higher scoring in this specific matchup. Given these factors, betting on the Over 7.5 total runs seems to be the most suitable choice.

Top Player Prop Picks

Bryan Woo (Seattle Mariners) - Pitcher Strikeouts Over 5.5

Bryan Woo has been in excellent form when it comes to strikeouts. He has hit the over on this line in 100% of his last 5 games, averaging 7.8 strikeouts, and 90% of his last 10 games, averaging 7.3 strikeouts. For the season, he has hit the over 72% of the time, with an average of 6.4 strikeouts. When pitching at home in 2025, he has hit the over 81.82% of the time, averaging 6.55 strikeouts. While his career strikeout rate against the current Padres roster is slightly lower, his recent dominant performances make the Over 5.5 strikeouts at +114 odds on FanDuel a strong play.

Ramón Laureano (San Diego Padres) - Bases Over 0.5

Ramón Laureano has been consistently getting on base, making the Over 0.5 Bases prop an attractive option. He has hit the over in 80% of his last 5 games, averaging 2.4 bases, and 80% of his last 10 games, averaging 2.3 bases. For the season, he has hit the over 62.26% of the time, with an average of 1.81 bases. Notably, against the Mariners in 2025, he has hit the over in 100% of his 2 appearances, averaging 5.0 bases. As a visitor in 2025, he has hit the over 59.18% of the time, averaging 2.02 bases. You can find the Over 0.5 Bases at -150 odds on Caesars.

Ryan O'Hearn (San Diego Padres) - Hits Over 0.5

Ryan O'Hearn presents a solid opportunity for the Over 0.5 Hits prop. He has hit the over in 80% of his last 5 games, averaging 1.2 hits, and 80% of his last 10 games, also averaging 1.2 hits. His season hit rate for the over is 62.39%, with an average of 0.91 hits. O'Hearn has performed well against the Mariners, hitting the over in 80% of his 5 appearances against them in 2025 (averaging 1.2 hits) and 83.33% of his 6 appearances in 2024 (averaging 1.17 hits). When playing as a visitor in 2025, he has hit the over 62.71% of the time, averaging 0.92 hits. The Over 0.5 Hits is available at -150 odds on BetMGM.