San Diego Padres @ New York Yankees Player Props, Picks and Predictions - 5/7/2025 7:05 PM EDT

We have your San Diego Padres @ New York Yankees prop betting and game preview needs covered as the New York Yankees hit the road to face the San Diego Padres.

San Diego Padres @ New York Yankees Pick

Best Moneyline Odds: Yankees -174, Padres +146 (Bet Now).
Best Spread Odds: Padres +1.5 (-195), Yankees -1.5 (+170) (Bet Now).
Best Total Odds: Over 8 (+100), Under 8 (-120) (Bet Now).

Game Info

Date: May 7, 2025
Time: 7:05 PM EDT
Location: Yankee Stadium, Bronx, NY
TV: ESPN

San Diego Padres @ New York Yankees Preview

The New York Yankees and San Diego Padres meet for the second game of their series at Yankee Stadium. The Yankees dominated the first game with a commanding 12-3 victory, showcasing their offensive firepower. The Padres, however, have been strong against the spread recently, going 5-0 ATS in their last five games. The Yankees, on the other hand, have struggled in interleague play, particularly as heavy favorites. This matchup will be pivotal for the Padres as they look to bounce back and even the series.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on May 6, 2025, the Yankees defeated the Padres 12-3, marking a strong offensive performance. Historically, the Yankees have struggled in interleague games as heavy favorites, going 2-8 in their last 10 such matchups. Meanwhile, the Padres have been solid in recent interleague play, winning five straight games outright. This head-to-head clash highlights the Yankees' home-field advantage but also the Padres' resilience in covering spreads.

Pick: Yankees Moneyline (-174)

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The Yankees' dominant performance in the first game of the series, combined with their home-field advantage, makes them the safer pick on the moneyline. While the Padres have been strong ATS, the Yankees' offensive momentum and ability to capitalize on mistakes give them the edge in this matchup. Expect the Yankees to secure another win, though it may not be as lopsided as the first game.

Top Player Prop Picks

1. Aaron Judge Over 1.5 Total Bases (+110)

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Aaron Judge has been a consistent force in the Yankees' lineup, and his ability to hit for power makes this prop appealing. Coming off a strong performance in the previous game, Judge is poised to continue his offensive surge against a Padres pitching staff that struggled in Game 1.

2. Juan Soto Over 0.5 Home Runs (+400)

Juan Soto remains a key offensive weapon for the Padres. Despite the team's struggles in the first game, Soto's power and ability to hit in clutch situations make this a high-value prop. Look for him to take advantage of any mistakes from the Yankees' pitching staff.

3. Gerrit Cole Over 7.5 Strikeouts (-125)

Gerrit Cole is the Yankees' ace and a strikeout machine. Facing a Padres lineup that can be prone to strikeouts, Cole is in a prime position to rack up Ks. His ability to dominate on the mound makes this prop a strong play.

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