San Diego Padres @ New York Yankees Player Props, Picks and Predictions - 5/6/2025 7:05 PM EDT

We have your San Diego Padres @ New York Yankees prop betting and game preview needs covered as the New York Yankees hit the road to face the San Diego Padres.

San Diego Padres @ New York Yankees Pick

Best Moneyline Odds: Yankees -110, Padres -106
Best Spread Odds: Padres +1.5 (-180), Yankees -1.5 (+150)
Best Total Odds: Over/Under 8.5 (-110)

Game Info

Date: May 6, 2025
Time: 7:05 PM EDT
Location: Yankee Stadium, Bronx, NY
TV: -

San Diego Padres @ New York Yankees Preview

The San Diego Padres are riding high on a five-game winning streak, including a narrow 4-3 victory over the Yankees in the series opener. The Yankees, on the other hand, have struggled recently, losing four of their last six games. Both teams are looking to make a statement in this matchup, with the Padres aiming to extend their streak and the Yankees seeking to bounce back at home.

Historic Head-to-Head Stats and Analysis

In their last five meetings, the Padres have had the upper hand, winning four of those matchups. The most recent game on May 5, 2025, saw the Padres edge out the Yankees 4-3 in a tightly contested battle. Historically, the Yankees have struggled to contain the Padres' offense, which has been a key factor in San Diego's success in this head-to-head series.

Pick: Padres Moneyline (-106)

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The Padres have been in excellent form, winning five straight games and showing resilience in close contests. Their recent success against the Yankees, combined with New York's inconsistent play, makes the Padres a strong pick to win outright. San Diego's ability to capitalize on scoring opportunities and their solid bullpen performance give them the edge in this matchup.

Top Player Prop Picks

1. Juan Soto Over 1.5 Total Bases (+120)

Juan Soto has been a key contributor for the Padres, consistently finding ways to get on base and deliver in clutch situations. With his ability to hit for power and average, Soto is a strong candidate to exceed 1.5 total bases in this game.

2. Aaron Judge Over 0.5 Home Runs (+250)

Aaron Judge remains the Yankees' most dangerous hitter, and his power at Yankee Stadium is well-documented. Facing a Padres pitching staff that has allowed home runs in recent games, Judge has a good chance to go deep in this matchup.

3. Blake Snell Over 6.5 Strikeouts (-110)

Blake Snell has been dominant on the mound for the Padres, and his ability to generate swings and misses makes this prop appealing. Against a Yankees lineup that has shown vulnerability to strikeouts, Snell should be able to rack up at least seven Ks.

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