San Diego Padres @ Miami Marlins Player Props, Picks and Predictions - 7/21/2025 6:40 PM EDT

We have your San Diego Padres @ Miami Marlins prop betting and game preview needs covered as the San Diego Padres hit the road to face the Miami Marlins.

San Diego Padres @ Miami Marlins Pick

Best Moneyline Odds: San Diego Padres +114, Miami Marlins -132
Best Spread Odds: -
Best Total Odds: -

Game Info

Date: July 21, 2025
Time: 6:40 PM EDT
Location: loanDepot Park, Miami, Florida
TV: -

San Diego Padres @ Miami Marlins Preview

The San Diego Padres (54-45) are set to visit loanDepot Park to take on the Miami Marlins (46-52) in what promises to be an intriguing matchup. The Padres are continuing their East Coast road trip, looking to build on their season record. The Marlins, despite their overall record, will be looking to turn things around at home. However, recent trends suggest a challenging path for Miami, as they have lost each of their last eight Monday games when playing as favorites. Furthermore, underdogs have emerged victorious in four of the Marlins' last five contests, indicating a potential vulnerability when Miami is expected to win. Probable starting pitchers are expected for both teams, but their names were not available at the time of this preview.

Historic Head-to-Head Stats and Analysis

Specific historical head-to-head statistical data for the San Diego Padres and Miami Marlins was not available in the provided research for this upcoming series.

Pick: San Diego Padres Moneyline (+114)

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Considering the recent struggles of the Miami Marlins when favored, particularly on Mondays where they've lost their last eight such games, and the general trend of underdogs winning four of their last five games against Miami, the San Diego Padres as the underdog present a compelling pick. The Padres have also shown a strong ability to cover the run line as an away underdog, doing so in 65.9% of their games. While this pick is for the moneyline, it underscores San Diego's capability to perform well on the road and potentially upset the favored Marlins.

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