Pittsburgh Pirates @ St. Louis Cardinals Player Props, Picks and Predictions - 5/6/2025 7:45 PM EDT

We have your Pittsburgh Pirates @ St. Louis Cardinals prop betting and game preview needs covered as the St. Louis Cardinals host the Pittsburgh Pirates in what promises to be an exciting matchup.

Pittsburgh Pirates @ St. Louis Cardinals Pick

Best Moneyline Odds: St. Louis Cardinals (+106) | Pittsburgh Pirates (-124)
Best Spread Odds: Pittsburgh Pirates -1.5 (+140) | St. Louis Cardinals +1.5 (-170)
Best Total Odds: Over/Under 8.5 runs (-)

Game Info

Date: May 6, 2025
Time: 7:45 PM EDT
Location: Busch Stadium, St. Louis, MO
TV: -

Pittsburgh Pirates @ St. Louis Cardinals Preview

The Pittsburgh Pirates and St. Louis Cardinals face off in the second game of their series after the Cardinals secured a 6-3 victory in the opener. The Pirates, who have struggled recently, will look to bounce back and even the series. Meanwhile, the Cardinals aim to build on their momentum and continue their strong performance at home.

Historic Head-to-Head Stats and Analysis

In their last 10 meetings, the St. Louis Cardinals have had the upper hand, winning 6 of those matchups. The Cardinals also claimed victory in the most recent game on May 5, 2025, with a 6-3 scoreline. Historically, the Cardinals have performed well at home against the Pirates, leveraging their home-field advantage effectively.

Pick: St. Louis Cardinals Moneyline (+106)

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The Cardinals have shown consistency in their recent head-to-head matchups against the Pirates, including their win in the series opener. With the momentum on their side and the Pirates struggling to find form, backing the Cardinals on the moneyline at plus odds offers solid value.

Top Player Prop Picks

1. Over 1.5 Total Bases - Key Player (PIT)

This player has been a consistent performer for the Pirates, with a strong track record of hitting for extra bases. Facing a Cardinals pitching staff that has allowed a fair share of hits recently, this prop is worth considering.

2. Over 4.5 Strikeouts - Starting Pitcher (STL)

The Cardinals' starting pitcher has been effective in generating strikeouts, particularly against teams with high strikeout rates like the Pirates. This line is achievable given the matchup.

3. Over 0.5 RBIs - Key Player (STL)

With the Cardinals' offense clicking in the series opener, this player is well-positioned to drive in runs again. He has been a reliable contributor in clutch situations.

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