Pittsburgh Pirates @ St. Louis Cardinals Player Props, Picks and Predictions - 5/5/2025 7:45 PM EDT

We have your Pittsburgh Pirates @ St. Louis Cardinals prop betting and game preview needs covered as the St. Louis Cardinals host the Pittsburgh Pirates in an exciting NL Central matchup.

Pittsburgh Pirates @ St. Louis Cardinals Pick

Best Moneyline Odds: St. Louis Cardinals -145, Pittsburgh Pirates +120.
Best Total Odds: Over/Under 8.5 runs (-110).

Game Info

Date: Monday, May 5, 2025
Time: 7:45 PM EDT
Location: Busch Stadium, St. Louis, MO
TV: -

Pittsburgh Pirates @ St. Louis Cardinals Preview

The St. Louis Cardinals come into this game as slight favorites, looking to build on their recent success after a narrow 5-4 victory over the New York Mets. Meanwhile, the Pittsburgh Pirates are aiming to bounce back from a tough 4-0 loss to the San Diego Padres. Both teams are battling for positioning in the NL Central, making this a critical early-season matchup.

The Cardinals have struggled as moneyline favorites this season, winning just 40% of such games. However, they have shown resilience at home, and their offense has been more consistent than the Pirates'. On the other hand, the Pirates have had difficulty as underdogs, winning only 7 of their last 21 games in that role. This game could hinge on pitching matchups and timely hitting, with both teams needing a strong performance to secure the win.

Historic Head-to-Head Stats and Analysis

In their last 10 head-to-head matchups, the Cardinals hold a slight edge over the Pirates, winning 6 of those games. St. Louis has also performed well at home against Pittsburgh, leveraging their home-field advantage. However, the Pirates have managed to keep several of these games close, often covering the spread as underdogs.

Pick: St. Louis Cardinals Moneyline (-145)

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The Cardinals' recent form and home-field advantage make them the safer pick in this matchup. While their overall record as favorites isn't stellar, they have shown the ability to win close games, as evidenced by their recent victories over the Mets. The Pirates' struggles as underdogs further bolster the case for St. Louis to secure the win.

Top Player Prop Picks

1. Over 1.5 Total Bases for Paul Goldschmidt

Goldschmidt has been a consistent force in the Cardinals' lineup, and his ability to hit for extra bases makes this prop appealing. Facing a Pirates pitching staff that has struggled at times, Goldschmidt is well-positioned to exceed this line.

2. Over 4.5 Strikeouts for Cardinals Starting Pitcher

The Pirates' lineup has been prone to strikeouts, and the Cardinals' starting pitcher should have opportunities to rack up Ks. This prop offers value given the Pirates' offensive inconsistencies.

3. Over 0.5 RBIs for Nolan Arenado

Arenado has been a clutch performer for the Cardinals, and with runners likely to be on base, he has a strong chance to drive in at least one run in this game.

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