New York Yankees @ Cleveland Guardians Player Props, Picks and Predictions - 4/22/2025 6:10 PM EDT

We have your New York Yankees @ Cleveland Guardians prop betting and game preview needs covered as the Cleveland Guardians hit the road to face the New York Yankees.

New York Yankees @ Cleveland Guardians Pick

Best Moneyline Odds: Cleveland Guardians -116, New York Yankees -102.
Best Spread Odds: Yankees +1.5 (-150), Guardians -1.5 (+130).
Best Total Odds: Over 8.5 (-110), Under 8.5 (-110).

Game Info

Date: April 22, 2025
Time: 6:10 PM EDT
Location: Yankee Stadium, Bronx, NY
TV: -

New York Yankees @ Cleveland Guardians Preview

The Cleveland Guardians and New York Yankees face off in the second game of their series after Cleveland secured a 6-4 victory in the opener. The Guardians, sitting at 13-9, have been strong when favored on the moneyline, boasting an 87.5% win rate in such situations. Meanwhile, the Yankees, at 14-9, are looking to bounce back and even the series. Both teams have shown offensive firepower, but pitching will likely play a pivotal role in this matchup.

Historic Head-to-Head Stats and Analysis

In their last 10 meetings, the Guardians hold a slight edge with a 6-4 record against the Yankees. Cleveland has also been effective at Yankee Stadium, winning 3 of their last 5 games there. The Yankees, however, have historically been strong at home and will look to leverage their home-field advantage to turn the tide in this series.

Pick: Cleveland Guardians Moneyline (-116)

The Guardians have been consistent when favored on the moneyline, winning 87.5% of such games this season. Their recent victory over the Yankees showcased their ability to capitalize on opportunities, and with momentum on their side, they are a strong pick to secure another win. The Yankees' inconsistency as underdogs further supports this selection.

Top Player Prop Picks

1. Aaron Judge Over 1.5 Total Bases (+110)

Aaron Judge has been a consistent offensive force for the Yankees. Despite the team's loss in the opener, Judge recorded a hit and has been a reliable contributor. With his power and ability to find gaps, he is a strong candidate to exceed 1.5 total bases in this game.

2. José Ramírez Over 0.5 RBIs (+125)

José Ramírez has been a key player for the Guardians, driving in runs in critical moments. With the Yankees' pitching staff showing vulnerabilities in the opener, Ramírez is well-positioned to add to his RBI tally in this matchup.

3. Gerrit Cole Over 7.5 Strikeouts (-105)

Gerrit Cole remains one of the most dominant pitchers in the league. Despite the Yankees' loss in the opener, Cole has consistently racked up strikeouts, and facing a Guardians lineup that can be prone to strikeouts, he is a strong bet to surpass 7.5 Ks.

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