Minnesota Twins @ Cleveland Guardians Player Props, Picks and Predictions - 5/1/2025 1:10 PM EDT

We have your Minnesota Twins @ Cleveland Guardians prop betting and game preview needs covered as the Cleveland Guardians hit the road to face the Minnesota Twins.

Minnesota Twins @ Cleveland Guardians Pick

Best Moneyline Odds: Cleveland Guardians -115 | Minnesota Twins -105
Best Spread Odds: Cleveland Guardians +1.5 (-194) | Minnesota Twins -1.5 (+160)
Best Total Odds: Over 9 (-120) | Under 9 (+100)

Game Info

Date: May 1, 2025
Time: 1:10 PM EDT
Location: Target Field, Minneapolis, MN
TV: -

Minnesota Twins @ Cleveland Guardians Preview

The Cleveland Guardians and Minnesota Twins face off in the final game of their series at Target Field. The Guardians secured a 4-2 victory in the previous matchup, showcasing strong pitching and timely hitting. Both teams are battling for positioning in the AL Central, making this game critical for momentum heading into the next stretch of the season. The Twins have been solid at home, while the Guardians have shown resilience on the road, setting up an intriguing contest.

Historic Head-to-Head Stats and Analysis

In their last 17 meetings, the under has hit 11 times, with 4 pushes, indicating a trend toward lower-scoring games. The Guardians have been competitive in recent matchups, winning 2 of the last 3 games in this series, including a 4-2 victory on April 30, 2025. The Twins, however, have been strong against the spread, going 6-1 ATS in their last 7 games, while the Guardians have struggled, going 1-4 ATS in their last 5 games.

Pick: Cleveland Guardians Moneyline (-115)

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The Guardians have been reliable as slight favorites, boasting a 9-2 record when playing as moneyline favorites of -115 or shorter. Their recent win against the Twins and solid pitching performance give them the edge in this matchup. While the Twins have been strong ATS, Cleveland's ability to capitalize on key moments makes them the pick for this game.

Top Player Prop Picks

1. Over 1.5 Total Bases - José Ramírez

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José Ramírez has been a consistent offensive force for the Guardians. With his ability to hit for extra bases and his recent form, he is a strong candidate to exceed 1.5 total bases in this game.

2. Over 5.5 Strikeouts - Pablo López

Pablo López, the Twins' starting pitcher, has been a strikeout machine this season. Facing a Guardians lineup that has shown vulnerability to strikeouts, López is well-positioned to surpass 5.5 strikeouts.

3. Over 0.5 RBIs - Josh Naylor

Josh Naylor has been clutch in run-scoring situations for Cleveland. With his ability to drive in runs, he is a strong pick to record at least one RBI in this game.

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