Minnesota Twins @ Cleveland Guardians Player Props, Picks and Predictions - 4/28/2025 6:10 PM EDT

We have your Minnesota Twins @ Cleveland Guardians prop betting and game preview needs covered as the Cleveland Guardians hit the road to face the Minnesota Twins.

Minnesota Twins @ Cleveland Guardians Pick

Best Moneyline Odds: Cleveland Guardians -125, Minnesota Twins +105.
Best Spread Odds: Cleveland Guardians -1.5 (+170), Minnesota Twins +1.5 (-196).
Best Total Odds: Over 8 (-106), Under 8 (-112).

Game Info

Date: April 28, 2025
Time: 6:10 PM EDT
Location: Target Field, Minneapolis, MN
TV: -

Minnesota Twins @ Cleveland Guardians Preview

The Minnesota Twins (12-16) host the Cleveland Guardians (15-12) in the first game of a crucial series. The Twins are coming off a dominant 5-0 win over the Los Angeles Angels, while the Guardians suffered a tough 13-3 loss to the Boston Red Sox. Both teams are looking to gain momentum in the AL Central standings. The Twins will send right-hander Bailey Ober to the mound. Ober has a 2-1 record in five starts this season but has struggled with a 5.04 ERA across 25 innings pitched. On the other side, the Guardians will counter with right-hander Gavin Williams, who has been solid in his outings. This matchup features two teams with contrasting recent performances. The Guardians have been strong as moneyline favorites this season, winning 88.9% of such games (8-1). However, the Twins have shown resilience at home, making this a tightly contested game.

Historic Head-to-Head Stats and Analysis

In their last five meetings, the Guardians hold a slight edge with a 3-2 record. The games have been closely contested, with an average margin of victory of just 2.4 runs. The Guardians have also been more successful on the road against the Twins, winning six of their last nine games at Target Field. However, the Twins' recent home win against the Angels could provide a confidence boost heading into this matchup.

Pick: Cleveland Guardians Moneyline (-125)

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The Guardians have been reliable as moneyline favorites this season, winning 88.9% of such games. With Gavin Williams on the mound and the Twins' Bailey Ober struggling with a high ERA, Cleveland has the edge in pitching. Additionally, the Guardians' recent success in head-to-head matchups and their ability to perform on the road make them the safer pick in this game.

Top Player Prop Picks

1. Bailey Ober Over 4.5 Strikeouts (-110)

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Despite his struggles with ERA, Ober has been consistent in racking up strikeouts. He has hit this mark in three of his last five starts, and the Guardians' lineup has shown vulnerability to strikeouts in recent games.

2. Jose Ramirez Over 1.5 Total Bases (+120)

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Ramirez has been a key offensive contributor for the Guardians, and he has a strong track record against right-handed pitching. With Ober's struggles, Ramirez is well-positioned to exceed this line.

3. Byron Buxton Over 0.5 Home Runs (+400)

Buxton has been heating up at the plate and has a favorable matchup against Gavin Williams, who has allowed multiple home runs in recent starts. Buxton's power makes this a high-value prop bet.