Detroit Lions at Arizona Cardinals Player Props, Picks and Predictions - 9/22/2024 4:25 PM EST

We have your Detroit Lions at Arizona Cardinals prop betting and game preview needs covered as the Detroit Lions hit the road to face the Arizona Cardinals.

Detroit Lions at Arizona Cardinals Odds Info

Best Moneyline Odds: Detroit Lions -146 (FanDuel) / Arizona Cardinals +158 (Caesars)
Best Spread Odds: 2.5 - Detroit Lions -118 (DraftKings) / 3.0 - Arizona Cardinals -115 (ESPN BET)
Best Total Odds: 52.5 - Under -110 (ESPN BET) / Over -110 (ESPN BET)

Game Info

Date: 9/22/2024
Time: 4:25 PM EST
Location: State Farm Stadium (Glendale, AZ)
TV: FOX

Detroit Lions at Arizona Cardinals Preview

The Detroit Lions and Arizona Cardinals are set to clash in a highly anticipated Week 3 matchup at State Farm Stadium. Both teams enter the game with a 1-1 record, but their paths to this point have been markedly different. The Lions are coming off a disappointing 20-16 loss to the Tampa Bay Buccaneers, a game in which they struggled mightily in the red zone, converting just one of seven opportunities into touchdowns. Quarterback Jared Goff threw for 307 yards but was hampered by two interceptions, and the Lions' inability to capitalize on Aidan Hutchinson's standout defensive performance, which included 4.5 sacks, proved costly.

In contrast, the Cardinals are riding high after a dominant 41-10 victory over the Los Angeles Rams. Arizona's offense, led by quarterback Kyler Murray, was firing on all cylinders. Murray posted a perfect passer rating, completing 17 of 21 passes for 266 yards and three touchdowns, while also adding 59 rushing yards. Rookie wide receiver Marvin Harrison Jr. showcased his potential with a breakout performance, catching four passes for 130 yards and two touchdowns, all in the first quarter. The Cardinals' defense also impressed, limiting the Rams to just 245 total yards and sacking Matthew Stafford five times.

As the Lions prepare to face the Cardinals, they will need to address their red zone inefficiencies and find a way to contain Arizona's dynamic offense. The Cardinals, on the other hand, will look to build on their momentum and exploit a Lions defense that has shown vulnerability. With both teams eager to secure a winning record, this matchup promises to be a compelling contest between two teams with contrasting styles and aspirations.

Detroit Lions at Arizona Cardinals Pick: Detroit Lions Moneyline

The Detroit Lions are poised to bounce back from their recent setback against the Tampa Bay Buccaneers, and the odds are in their favor as they face the Arizona Cardinals. Despite their 20-16 loss to the Buccaneers, the Lions demonstrated resilience and potential, particularly on the defensive side of the ball. Aidan Hutchinson's remarkable performance, which included 4.5 sacks, showcased the Lions' ability to disrupt opposing offenses. This defensive prowess will be crucial in containing Arizona's dynamic quarterback, Kyler Murray, who is coming off a stellar game against the Rams.

While the Cardinals impressed with a 41-10 victory over the Rams, it's important to note that the Rams were without key players like Puka Nacua, and Cooper Kupp left the game with an injury. The Lions, on the other hand, have a history of bouncing back from early-season losses, as evidenced by their ability to regroup after a Week 2 defeat last year. Jared Goff, despite his two interceptions against the Buccaneers, threw for over 300 yards and has the potential to exploit a Cardinals defense that was vulnerable in their Week 1 loss to the Bills.

Moreover, the Lions' offense, led by Goff and supported by a strong receiving corps, has the capability to challenge the Cardinals' secondary. The Lions' red zone struggles against the Buccaneers are likely to be addressed, and with a more balanced offensive approach, they can capitalize on scoring opportunities. The Lions' determination to avoid falling below .500 and their ability to learn from past mistakes make them a formidable opponent for the Cardinals. With the Lions opening as three-point road favorites, the betting lines reflect confidence in their ability to secure a victory. Expect the Lions to leverage their defensive strengths and offensive adjustments to emerge victorious in this crucial matchup.

Detroit Lions at Arizona Cardinals Top Player Prop Picks

Kyler Murray Over 266.5 Passing Yards Passing Yards -110 (DraftKings)

Kyler Murray is coming off a stellar performance against the Los Angeles Rams, where he completed 17 of 21 passes for 266 yards and three touchdowns, achieving a perfect passer rating. His ability to connect with rookie wide receiver Marvin Harrison Jr., who had a breakout game with 130 yards and two touchdowns, highlights the dynamic nature of Arizona's passing attack. The Lions' defense, while formidable with Aidan Hutchinson's 4.5 sacks against the Buccaneers, showed vulnerabilities in the secondary that Murray can exploit. Given his recent form and the Cardinals' offensive momentum, betting on Murray to exceed 266.5 passing yards seems a prudent choice.

Marvin Harrison Jr. Over 1.5 Receiving Touchdowns +150 (FanDuel)

Marvin Harrison Jr. made a significant impact in his second NFL game, scoring two touchdowns in the first quarter against the Rams. His chemistry with Kyler Murray was evident, and the Cardinals will likely continue to feature him prominently in their offensive scheme. The Lions' secondary struggled to contain the Buccaneers' passing game, and with Cooper Kupp's injury limiting the Rams' options, Harrison Jr. capitalized on his opportunities. With the Cardinals' offense firing on all cylinders, Harrison Jr. is poised to find the end zone multiple times again, making the over on 1.5 receiving touchdowns an enticing proposition.

James Conner Over 100.5 Rushing Yards -105 (Caesars)

James Conner was a force on the ground against the Rams, rushing for 122 yards on 21 carries. The Cardinals' offensive line created ample running lanes, allowing Conner to average 5.8 yards per carry. The Lions' defense, while strong in pass rush, has shown susceptibility to the run, as evidenced by their struggles in containing the Buccaneers' ground game. With the Cardinals likely to establish the run early to set up their play-action passing, Conner is in a prime position to surpass 100.5 rushing yards. His consistent performance and the Cardinals' balanced offensive approach make this a solid bet.