Houston Astros @ St. Louis Cardinals Player Props, Picks and Predictions - 4/16/2025 1:15 PM EDT

We have your Houston Astros @ St. Louis Cardinals prop betting and game preview needs covered as the St. Louis Cardinals hit the road to face the Houston Astros.

Houston Astros @ St. Louis Cardinals Pick

Best Moneyline Odds: Houston Astros -126 | St. Louis Cardinals +108
Best Spread Odds: Houston Astros -1.5 (+136) | St. Louis Cardinals +1.5 (-164)
Best Total Odds: Over 7.5 (-110) | Under 7.5 (-110)

Game Info

Date: April 16, 2025
Time: 1:15 PM EDT
Location: Busch Stadium, St. Louis, MO
TV: -

Houston Astros @ St. Louis Cardinals Preview

The Houston Astros and St. Louis Cardinals meet for the second game of their series at Busch Stadium. The Astros took the first game with a 2-0 victory, showcasing strong pitching and timely hitting. Both teams enter this matchup with identical 8-9 records, making this game pivotal as they aim to climb back to .500. The Astros have been solid on the road, while the Cardinals look to bounce back at home with their offense needing a spark.

Historic Head-to-Head Stats and Analysis

In their last matchup on April 15, 2025, the Astros defeated the Cardinals 2-0, with Houston's pitching staff shutting down the Cardinals' offense. Historically, these teams have played competitive games, with the Astros holding a slight edge in recent meetings. The Cardinals have struggled to generate runs against Houston's pitching, which could be a key factor in this game.

Pick: Houston Astros Moneyline (-126)

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The Astros' recent form and strong pitching performance in the previous game make them the better pick for this matchup. Houston's ability to limit the Cardinals' offense, combined with their road success, gives them the edge. The Cardinals' inconsistency at the plate further supports this pick.

Top Player Prop Picks

1. Over 1.5 Total Bases - Yordan Alvarez (+120)

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Yordan Alvarez has been a consistent offensive force for the Astros. With his ability to hit for power and get on base, he is a strong candidate to exceed 1.5 total bases in this game. Look for him to capitalize on any mistakes from the Cardinals' pitching staff.

2. Over 5.5 Strikeouts - Astros Starting Pitcher (-)

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The Astros' starting pitcher dominated in the previous game, and with the Cardinals' offense struggling, this line is appealing. Expect another strong outing with plenty of strikeouts against a lineup that has shown vulnerability.

3. Over 0.5 RBIs - Paul Goldschmidt (+110)

Paul Goldschmidt remains a key offensive weapon for the Cardinals. If the Cardinals can generate baserunners, Goldschmidt is likely to drive in runs, making this prop a solid choice.

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