Denver Broncos at Buffalo Bills Player Props, Picks and Predictions - 1/12/2025 1:00 PM EST

We have your Denver Broncos at Buffalo Bills prop betting and game preview needs covered as the Denver Broncos hit the road to face the Buffalo Bills.

Denver Broncos at Buffalo Bills Odds Info

Best Moneyline Odds: Denver Broncos +400 (BetMGM) / Buffalo Bills -455 (BetRivers)
Best Spread Odds: -9.5 - Denver Broncos -110 (ESPN BET) / -8.5 - Buffalo Bills -110 (bet365)
Best Total Odds: 47.5 - Under -110 (DraftKings) / Over -105 (ESPN BET)

Game Info

Date: 1/12/2025
Time: 1:00 PM EST
Location: Highmark Stadium (Orchard Park, NY)
TV: CBS

Historic Head-to-Head Stats and Analysis

In the past three seasons, the Denver Broncos and Buffalo Bills have faced each other once, with the Broncos emerging victorious. This game took place on November 13, 2023, and saw the visiting Broncos defeat the home team Bills. The Broncos also covered the spread in this matchup, as they were the underdogs with a closing spread of +7.5. The game did not hit the over, with a total score of 46 points against a closing over-under of 47.5. This singular encounter provides a limited but clear picture of the recent dynamics between these two teams, with Denver holding the upper hand both in terms of the outright win and against the spread.

In the most recent game, the Denver Broncos secured a narrow 24-22 victory over the Buffalo Bills. The Broncos' scoring was highlighted by a 40-yard field goal by Wil Lutz in the first quarter, followed by a 7-yard touchdown pass from Russell Wilson to Courtland Sutton and another field goal by Lutz in the second quarter. Denver led 15-8 at halftime. The Bills responded with a 22-yard touchdown pass from Josh Allen to Dalton Kincaid and a successful two-point conversion. In the second half, Latavius Murray scored a 3-yard rushing touchdown for Buffalo, tying the game at 15-15. Wilson then connected with Javonte Williams for a 3-yard touchdown pass, but Allen answered with a 6-yard rushing touchdown to put the Bills ahead 22-21. Lutz capped the scoring with a 36-yard field goal as time expired, securing the win for Denver.

Statistically, the Broncos recorded 300 total yards, with 178 passing and 122 rushing yards, while the Bills amassed 369 total yards, including 177 passing and 192 rushing yards. Denver's defense was instrumental in the victory, forcing four turnovers from Buffalo, including two interceptions thrown by Josh Allen. The Broncos' offense was efficient, with Russell Wilson completing 24 of 29 passes for a completion percentage of 82.76%. Despite being sacked four times, Wilson's performance was crucial in securing the win. The Bills, on the other hand, struggled with turnovers, which ultimately contributed to their narrow defeat.

Denver Broncos at Buffalo Bills Preview

The Denver Broncos are set to face the Buffalo Bills in a highly anticipated Wild Card matchup, marking their first playoff appearance since 2015. Under the guidance of head coach Sean Payton, the Broncos have revitalized their franchise, finishing the regular season with a 10-7 record. Rookie quarterback Bo Nix has been instrumental in this turnaround, showcasing his development with a stellar performance against the Kansas City Chiefs, where he threw for over 300 yards and four touchdowns. Denver's defense, led by standout cornerback Patrick Surtain Jr., has been a formidable force, consistently applying pressure and forcing turnovers, which will be crucial against a potent Bills offense.

The Buffalo Bills, on the other hand, enter the playoffs as the No. 2 seed in the AFC with a 13-4 record. Led by MVP favorite Josh Allen, the Bills boast one of the league's most explosive offenses, capable of scoring both through the air and on the ground. Allen's dual-threat ability, combined with a deep receiving corps bolstered by the midseason addition of Amari Cooper, makes Buffalo a formidable opponent. However, the Bills' defense has shown vulnerabilities, particularly in high-scoring games, which could be an area the Broncos look to exploit.

Historically, the Broncos have had recent success against the Bills, having defeated them in their last meeting during the 2023 regular season. In that game, Denver's defense was pivotal, forcing multiple turnovers and limiting Buffalo's offensive output. As the Broncos prepare for this playoff clash, they will rely on their defensive prowess and the emerging talent of Bo Nix to challenge the Bills in what promises to be a thrilling encounter at Highmark Stadium.

Denver Broncos at Buffalo Bills Pick: Buffalo Bills Moneyline

As the Denver Broncos prepare to face the Buffalo Bills in the Wild Card round, the odds heavily favor the home team, Buffalo. The Bills, entering the playoffs as the No. 2 seed in the AFC with a 13-4 record, have demonstrated their prowess throughout the season, led by MVP favorite Josh Allen. Allen's dual-threat capabilities, both as a passer and a runner, have been instrumental in Buffalo's offensive success, making them one of the most formidable teams in the league. The Bills' offense, bolstered by the midseason addition of Amari Cooper, has consistently put up high-scoring performances, which will be a significant challenge for the Broncos' defense to contain.

While the Broncos have shown resilience and improvement under head coach Sean Payton, finishing the regular season with a 10-7 record, their path to the playoffs was marked by inconsistency. Rookie quarterback Bo Nix has shown promise, particularly in the decisive victory over the Kansas City Chiefs, but the challenge of facing a seasoned playoff team like the Bills is a different magnitude. Denver's defense, although strong, will need to be at its absolute best to disrupt Allen and the Bills' high-powered offense.

Historically, the Bills have a slight edge over the Broncos, holding a 23-17-1 all-time series lead. Despite Denver's narrow victory over Buffalo in their last meeting during the 2023 regular season, the stakes are much higher now, and the Bills' playoff experience could prove decisive. Buffalo's recent form, including statement wins over top teams like the Chiefs and Lions, underscores their capability to perform under pressure. Given these factors, the Buffalo Bills are well-positioned to secure a victory at home, making them the favored pick for the moneyline in this Wild Card matchup.

Denver Broncos at Buffalo Bills Top Player Prop Picks

Bo Nix Over 223.5 Passing Yards -114 (FanDuel)

Bo Nix has been a revelation for the Denver Broncos, especially in the latter part of the season. His performance against the Kansas City Chiefs, where he threw for over 300 yards and four touchdowns, underscores his capability to deliver under pressure. As the Broncos head into a crucial Wild Card matchup against the Buffalo Bills, Nix's passing prowess will be pivotal. The Bills' defense, while formidable, has shown vulnerabilities, particularly in high-scoring games. Given Nix's recent form and the Broncos' reliance on his arm to navigate their offensive strategy, betting on Nix to surpass 223.5 passing yards seems a prudent choice.

Josh Allen Over 1.5 Passing TDs -100 (FanDuel)

Josh Allen, the MVP favorite, has been the linchpin of the Buffalo Bills' explosive offense. With 40 combined touchdowns this season, Allen's ability to find the end zone is well-documented. The Broncos' defense, though strong, will face a significant challenge in containing Allen's dual-threat capabilities. Given the stakes of this playoff game and Allen's track record of rising to the occasion, expecting him to throw for more than 1.5 touchdowns is a solid proposition. The Bills' deep receiving corps, bolstered by Amari Cooper, provides Allen with ample targets to exploit Denver's secondary.

Courtland Sutton Over 64.5 Receiving Yards -114 (FanDuel)

Courtland Sutton has been a key target for Bo Nix, and his role will be crucial in the Broncos' offensive game plan against the Bills. Sutton's ability to make big plays downfield is well-known, and with Nix's recent form, the chemistry between the two is likely to be a focal point in Denver's strategy. The Bills' defense, which has shown susceptibility to high-powered offenses, could struggle to contain Sutton, especially if Nix continues to distribute the ball effectively. With the Broncos needing to keep pace with Buffalo's potent offense, Sutton is poised to have a significant impact, making the over on 64.5 receiving yards an attractive bet.