Colorado Buffaloes @ Houston Cougars Player Props, Picks and Predictions - 9/12/2025 7:30 PM EDT

We have your Colorado Buffaloes @ Houston Cougars prop betting and game preview needs covered as the Colorado Buffaloes hit the road to face the Houston Cougars.

Colorado Buffaloes @ Houston Cougars Pick

Best Moneyline Odds: Houston Cougars -182.0 on BetRivers | Colorado Buffaloes +165 on BetMGM
Best Spread Odds: Houston Cougars -4.0 (-110) on Caesars | Colorado Buffaloes +4.5 (-110) on ESPN BET
Best Total Odds: Over 43.5 (-110) on Fanduel | Under 44.5 (-115) on ESPN BET

Game Info

Date: 2025-09-12
Time: 7:30 PM EDT
Location: Houston, TX
TV: ESPN

Colorado Buffaloes @ Houston Cougars Preview

The Colorado Buffaloes (1-1) head to Houston to face the Cougars (2-0) in what promises to be a pivotal early-season matchup. Colorado is looking to find its stride in Deion Sanders' third season, having started with a close loss to Georgia Tech and a somewhat shaky win against Delaware where three different quarterbacks saw action. This game marks the beginning of their Big 12 schedule, making it a crucial test for the new-look Buffaloes squad still gelling.

The Houston Cougars enter this contest with a perfect 2-0 record, fresh off a dominant 35-9 victory over crosstown rival Rice. Houston's offense, revamped through the transfer portal, appears balanced and efficient under second-year head coach Willie Fritz. Quarterback Conner Weigman, a former five-star recruit and Texas A&M transfer, has been careful with the ball, completing over 65% of his passes for 347 yards and four touchdowns without an interception. His primary target has been Ball State transfer tight end Tanner Koziol, who leads the team with 13 catches for 115 yards and a touchdown. The Cougars' rushing attack has also been formidable, led by running back Dean Connors, who boasts 182 yards and two touchdowns, averaging 6.5 yards per carry with two runs exceeding 40 yards.

Defensively, Houston has been stout under new defensive coordinator Austin Armstrong, holding opponents to a mere 9 total points and 186 yards per game through their first two outings. Florida International transfer Eddie Walls III has made an immediate impact on the defensive line with three tackles for loss, including a sack. Linebacker Jalen Garner and cornerback Latrell McCutchin Sr. have continued their strong play from last season. The Cougars' defense will face a unique challenge as Colorado's quarterback situation remains uncertain, with both Ryan Staub and Kaidon Salter potentially seeing snaps, forcing Houston to prepare for multiple looks.

Historic Head-to-Head Stats and Analysis

Information regarding the historic head-to-head statistics and analysis between the Colorado Buffaloes and Houston Cougars is not available in the provided research.

Pick: Houston Cougars -4.0

The Houston Cougars, playing at home, present a strong case to cover the spread against the Colorado Buffaloes. Houston's defense has been exceptionally stingy through two games, allowing minimal points and yardage, which bodes well against a Colorado offense that is still trying to establish consistency and clarity at the quarterback position. The Buffaloes' struggles against the run in Week 1 and the pass against Delaware suggest Houston's balanced offensive attack, featuring a reliable quarterback in Conner Weigman and an effective ground game led by Dean Connors, will be able to exploit these vulnerabilities. While Colorado has aspirations for their Big 12 debut, Houston's solid defensive foundation and efficient offense make them a confident pick to win by more than a field goal. You can find the best odds for Houston -4.0 at Caesars.