Cincinnati Reds @ Pittsburgh Pirates Player Props, Picks and Predictions - 5/21/2025 12:35 PM EDT

We have your Cincinnati Reds @ Pittsburgh Pirates prop betting and game preview needs covered as the Pittsburgh Pirates hit the road to face the Cincinnati Reds.

Cincinnati Reds @ Pittsburgh Pirates Pick

Best Moneyline Odds: Reds -141, Pirates +120 (Bet Now)
Best Spread Odds: Reds -1.5 (+115), Pirates +1.5 (-152) (Bet Now)
Best Total Odds: Over/Under 8 runs (Bet Now)

Game Info

Date: May 21, 2025
Time: 12:35 PM EDT
Location: PNC Park, Pittsburgh, PA
TV: -

Cincinnati Reds @ Pittsburgh Pirates Preview

The Cincinnati Reds, sitting at 25-24, are looking to build momentum after a narrow 1-0 loss to the Pirates in the previous game. The Pirates, struggling with a 15-33 record, are desperate to find consistency and turn their season around. The Reds have been solid when favored on the moneyline, winning 54.2% of such games this season. Meanwhile, the Pirates have had a tough time, with their pitching and offense both underperforming. This matchup will feature Brady Singer (5-2, 4.82 ERA) for the Reds and Andrew Heaney (2-3, 3.02 ERA) for the Pirates, setting up an intriguing pitching duel.

Historic Head-to-Head Stats and Analysis

In their recent head-to-head matchups, the Reds have dominated the Pirates. On May 19, 2025, the Reds secured a convincing 7-1 victory, covering the spread as -1.5 favorites. However, the Pirates bounced back on May 20, 2025, with a narrow 1-0 win. Earlier in the season, on April 13, 2025, the Reds shut out the Pirates 4-0. Overall, the Reds have had the upper hand in this matchup, showcasing stronger pitching and timely hitting.

Pick: Reds Moneyline (-141)

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The Reds are the better team in this matchup, with a more consistent offense and a solid track record against the Pirates this season. Brady Singer has been reliable on the mound, and the Reds' ability to capitalize on scoring opportunities gives them the edge. The Pirates' struggles, particularly on offense, make it difficult to trust them in this spot. Back the Reds to win outright.

Top Player Prop Picks

1. Brady Singer Over 5.5 Strikeouts

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Singer has been a strikeout machine this season, and the Pirates' lineup has struggled against right-handed pitching. With Singer averaging over a strikeout per inning, he is well-positioned to surpass this line.

2. Andrew Heaney Under 2.5 Earned Runs

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Despite the Pirates' struggles, Heaney has been a bright spot with a 3.02 ERA. He has shown the ability to limit damage, and the Reds' offense has been inconsistent at times, making this a solid play.

3. Jonathan India Over 1.5 Total Bases

India has been a key contributor for the Reds, consistently getting on base and driving the ball. Against Heaney, he has a favorable matchup to rack up multiple bases, whether through hits or extra-base power.

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