Chicago White Sox @ Minnesota Twins Player Props, Picks and Predictions - 4/22/2025 7:40 PM EDT

We have your Chicago White Sox @ Minnesota Twins prop betting and game preview needs covered as the Minnesota Twins host the Chicago White Sox in an AL Central showdown.

Chicago White Sox @ Minnesota Twins Pick

Best Moneyline Odds: Minnesota Twins -245, Chicago White Sox +200.
Best Total Odds: Over/Under 8.5 runs (-105 for the Over, -115 for the Under).

Game Info

Date: April 22, 2025
Time: 7:40 PM EDT
Location: Target Field, Minneapolis, MN
TV: -

Chicago White Sox @ Minnesota Twins Preview

The Minnesota Twins enter this matchup as heavy favorites, boasting a moneyline of -245. The Chicago White Sox, on the other hand, are significant underdogs at +200. Both teams have struggled early in the season, with the Twins holding a 7-15 record and the White Sox at 5-17. Minnesota will rely on Bailey Ober (1-1, 6.16 ERA) to lead their pitching staff, while Chicago counters with Davis Martin (1-2, 4.84 ERA). This game could be pivotal for both teams as they look to gain momentum in the AL Central.

Historic Head-to-Head Stats and Analysis

In their last 12 meetings over the past three seasons, the Chicago White Sox and Minnesota Twins are tied with a 6-6 record. This even split highlights the competitive nature of their rivalry, with neither team gaining a clear upper hand in recent history.

Pick: Minnesota Twins Moneyline (-245)

The Minnesota Twins are the clear favorites in this matchup, and for good reason. With Bailey Ober on the mound, they have a slight edge in pitching, despite his high ERA. The White Sox have struggled mightily this season, winning just 22.7% of their games as underdogs. Minnesota’s home-field advantage and superior lineup make them the safer pick for this game.

Top Player Prop Picks

1. Bailey Ober Over 5.5 Strikeouts

Ober has shown the ability to rack up strikeouts, and facing a White Sox lineup that has struggled offensively, this line is achievable. Chicago’s high strikeout rate against right-handed pitchers further supports this pick.

2. Luis Robert Jr. Over 1.5 Total Bases

Robert Jr. has been one of the few bright spots for the White Sox this season. His power and ability to hit for extra bases make this a strong play, especially against a pitcher like Ober who has been inconsistent.

3. Carlos Correa Over 0.5 RBIs

Correa is a key piece of the Twins’ offense and has a knack for driving in runs in clutch situations. With the White Sox’s pitching struggles, Correa is well-positioned to capitalize and drive in at least one run.

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