Chicago Cubs @ St. Louis Cardinals Player Props, Picks and Predictions - 6/26/2025 2:15 PM EDT

We have your Chicago Cubs @ St. Louis Cardinals prop betting and game preview needs covered as the Chicago Cubs hit the road to face the St. Louis Cardinals.

Chicago Cubs @ St. Louis Cardinals Pick

Best Moneyline Odds: Chicago Cubs -142, St. Louis Cardinals +120.
Best Spread Odds: Chicago Cubs -1.5 (+126), St. Louis Cardinals +1.5 (-152).
Best Total Odds: Over 9 (-115), Under 9 (-105).

Game Info

Date: June 26, 2025
Time: 2:15 PM EDT
Location: Busch Stadium, St. Louis, Missouri
TV: -

Chicago Cubs @ St. Louis Cardinals Preview

The Chicago Cubs and St. Louis Cardinals face off in the second game of their series at Busch Stadium. The Cubs dominated the Cardinals in the first game, securing an 8-0 victory behind a strong offensive performance and solid pitching. The Cardinals will look to bounce back and even the series, but they face a tough challenge against a Cubs team that has been consistent as road favorites this season.

Historic Head-to-Head Stats and Analysis

In their most recent matchup on June 25, 2025, the Cubs shut out the Cardinals 8-0, showcasing their offensive firepower and pitching depth. Over the last 10 meetings between these teams, the Cubs have had the upper hand, winning 7 of those games. The Cardinals have struggled to contain the Cubs' bats, particularly in high-scoring games.

Pick: Chicago Cubs Moneyline (-142)

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The Cubs have been reliable as moneyline favorites this season, boasting a 37-18 record in such situations. Coming off a dominant win in the series opener, they have the momentum and the edge in both pitching and offensive consistency. The Cardinals, while playing at home, have struggled to find rhythm against the Cubs in recent matchups. Backing the Cubs on the moneyline is the most logical choice here.

Top Player Prop Picks

1. Over 5.5 Strikeouts for Cubs Starting Pitcher

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The Cubs' starting pitcher has been effective in generating strikeouts, particularly against teams like the Cardinals, who have shown vulnerability to high strikeout totals. This line offers value given the Cardinals' recent offensive struggles.

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