Chicago Cubs @ St. Louis Cardinals Player Props, Picks and Predictions - 6/24/2025 7:45 PM EDT

We have your Chicago Cubs @ St. Louis Cardinals prop betting and game preview needs covered as the Chicago Cubs hit the road to face the St. Louis Cardinals.

Chicago Cubs @ St. Louis Cardinals Pick

Best Moneyline Odds: Cubs -115 | Cardinals +103
Best Spread Odds: Cubs -1.5 (+136) | Cardinals +1.5 (-162)
Best Total Odds: Over/Under 9 (-110)

Game Info

Date: June 24, 2025
Time: 7:45 PM EDT
Location: Busch Stadium, St. Louis, MO
TV: -

Chicago Cubs @ St. Louis Cardinals Preview

The Chicago Cubs and St. Louis Cardinals continue their NL Central rivalry at Busch Stadium. The Cardinals are coming off a dominant 8-2 victory over the Cubs in the series opener, showcasing their offensive firepower. The Cubs, however, will look to bounce back and even the series. Both teams are in the thick of the division race, making this matchup critical for momentum and standings.

Historic Head-to-Head Stats and Analysis

Over the last five years, the Chicago Cubs hold a slight edge in head-to-head matchups, going 14-12 against the St. Louis Cardinals. In their most recent 10 meetings, the Cubs have won six games, while the Cardinals have taken four. The Cardinals' win in the series opener adds to their recent success, but the Cubs have shown resilience in this rivalry.

Pick: St. Louis Cardinals Moneyline (+103)

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The Cardinals' recent 8-2 victory and home-field advantage make them an appealing pick at plus money. Their offense looked sharp in the opener, and they’ll aim to carry that momentum into this game. The Cubs, while competitive, have struggled to find consistency in this matchup, making the Cardinals a solid value play.

Top Player Prop Picks

1. Paul Goldschmidt Over 1.5 Total Bases (+120)

Goldschmidt has been a consistent force for the Cardinals and thrives in home games. With his ability to hit for power and find gaps, he’s a strong candidate to surpass this line.

2. Seiya Suzuki Over 0.5 Home Runs (+400)

Suzuki has been heating up at the plate, including a two-home-run performance in a recent game. His power potential makes this a high-value prop to consider.

3. Miles Mikolas Over 5.5 Strikeouts (+110)

Mikolas has been effective at generating strikeouts, especially against teams like the Cubs that can be prone to swings and misses. Look for him to hit this mark if he pitches deep into the game.

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