Arizona Cardinals at Buffalo Bills Player Props, Picks and Predictions - 9/8/2024 1:00 PM EST

We have your Arizona Cardinals at Buffalo Bills prop betting and game preview needs covered as the Arizona Cardinals hit the road to face the Buffalo Bills.

Arizona Cardinals at Buffalo Bills Odds Info

Best Moneyline Odds: Arizona Cardinals +240 (Caesars) / Buffalo Bills -290 (FanDuel)
Best Spread Odds: -6.0 - Arizona Cardinals -105 (Caesars) / Buffalo Bills -115 (Caesars)
Best Total Odds: 48.0 - Under -110 (bet365) / Over -110 (bet365)

Game Info

Date: 9/8/2024
Time: 1:00 PM EST
Location: Highmark Stadium (Orchard Park, NY)
TV: CBS

Arizona Cardinals at Buffalo Bills Preview

The Arizona Cardinals and Buffalo Bills are set to clash in an intriguing Week 1 matchup at Highmark Stadium. This game marks a significant moment for both teams as they look to set the tone for their respective 2024 campaigns. The Bills, coming off a strong 11-6 season, are eager to maintain their dominance in the AFC East despite some key departures, including star receiver Stefon Diggs. Quarterback Josh Allen, who accounted for 44 combined touchdowns last season, will be tasked with leading a revamped offense featuring new faces like second-round pick Keon Coleman and breakout receiver Khalil Shakir.

On the other side, the Cardinals are optimistic about their prospects after a challenging 4-win season. With a healthy Kyler Murray at the helm, Arizona's offense is poised for a resurgence. The addition of rookie wideout Marvin Harrison Jr., selected fourth overall in the 2024 draft, adds a dynamic element to their passing attack. Tight end Trey McBride, who led the team in receptions and receiving yards last season, will also be a key target for Murray.

Defensively, the Bills will rely on their new starting safety duo of Damar Hamlin and Taylor Rapp to contain Arizona's explosive playmakers. Hamlin, who has overcome significant adversity following his cardiac arrest in early 2023, is set to make his first start since the incident. The Cardinals, meanwhile, will need to address their defensive vulnerabilities if they hope to compete against a potent Buffalo offense.

Historically, the Bills have had the upper hand in this matchup, leading the all-time series 7-5. However, the Cardinals' last victory in Buffalo dates back to 1971, a streak they are eager to break. With both teams undergoing transitions and looking to establish their identities early in the season, this game promises to be a compelling contest.

Arizona Cardinals at Buffalo Bills Pick: Buffalo Bills Moneyline

The Buffalo Bills enter their Week 1 matchup against the Arizona Cardinals as a team in transition, yet they remain a formidable force, especially at home. Despite the offseason departure of star receiver Stefon Diggs, the Bills have consistently demonstrated resilience and adaptability under the leadership of quarterback Josh Allen. Allen, who accounted for an impressive 44 combined touchdowns last season, is expected to continue his high-level play, even as he adjusts to new offensive weapons like second-round pick Keon Coleman and emerging receiver Khalil Shakir.

Historically, the Bills have dominated this matchup, leading the all-time series 7-5, and they have not lost to the Cardinals at home since their first-ever meeting in 1971. This historical edge, combined with the home-field advantage at Highmark Stadium, where the Bills have been particularly strong, bolsters their position as favorites in this contest.

Defensively, the Bills will rely on the newly appointed starting safety duo of Damar Hamlin and Taylor Rapp. Hamlin's return to the starting lineup is not only a testament to his perseverance but also a strategic move by head coach Sean McDermott, who values consistency and resilience. The Bills' defense will be tasked with containing Arizona's promising offensive talents, including rookie wideout Marvin Harrison Jr. and tight end Trey McBride. However, the Cardinals' defense remains a concern, lacking the high-end potential needed to consistently challenge a team of Buffalo's caliber.

While the Cardinals have made strides offensively with a healthy Kyler Murray and the addition of Harrison Jr., their defensive vulnerabilities could be exploited by a Bills team eager to prove their mettle in the AFC East. Given these factors, the Buffalo Bills are well-positioned to secure a victory in their season opener, making them the favored pick on the moneyline.

Arizona Cardinals at Buffalo Bills Top Player Prop Picks

Josh Allen Over 1.5 Passing TDs -134 (BetRivers)

Josh Allen has consistently been a dominant force for the Buffalo Bills, and despite the offseason changes, he remains the linchpin of their offense. Last season, Allen accounted for 44 combined touchdowns, showcasing his ability to find the end zone both through the air and on the ground. With the departure of Stefon Diggs, Allen will be looking to establish a connection with new targets like Keon Coleman and Khalil Shakir. The Cardinals' defense, while improved, still lacks the high-end potential to consistently contain a quarterback of Allen's caliber. Given Allen's track record and the Bills' historical success against the Cardinals, betting on Allen to throw over 1.5 passing touchdowns seems a solid choice.

Marvin Harrison Jr. Over 5.5 Receptions +110 (BetMGM)

Marvin Harrison Jr. enters the NFL with high expectations as the fourth overall pick in the 2024 draft. The Cardinals are eager to integrate him into their offense, and his debut against the Bills presents a prime opportunity. With Kyler Murray healthy and ready to lead Arizona's offense, Harrison Jr. is poised to be a primary target, especially given the absence of Xavier Weaver due to injury. The Bills' secondary, featuring new starters Damar Hamlin and Taylor Rapp, will have their hands full containing Harrison Jr., who is expected to be heavily involved in the Cardinals' passing game. The odds favor Harrison Jr. to exceed 5.5 receptions, making this a compelling prop bet.

Trey McBride Over 5.5 Receptions +115 (BetMGM)

Trey McBride emerged as a key offensive weapon for the Cardinals last season, leading the team in receptions and receiving yards. With Kyler Murray back at the helm and the addition of Marvin Harrison Jr. drawing defensive attention, McBride is likely to find himself in favorable matchups. The Bills' defense, while strong, will be adjusting to new personnel in the secondary, which could open up opportunities for McBride to exploit. Given his role in the offense and the expected game script, McBride is well-positioned to surpass 5.5 receptions, offering value at +115 odds.