Buffalo Bills at Indianapolis Colts Player Props, Picks and Predictions - 11/10/2024 1:00 PM EST

We have your Buffalo Bills at Indianapolis Colts prop betting and game preview needs covered as the Buffalo Bills hit the road to face the Indianapolis Colts.

Buffalo Bills at Indianapolis Colts Odds Info

Best Moneyline Odds: Buffalo Bills -210 (bet365) / Indianapolis Colts +175 (bet365)
Best Spread Odds: 4.0 - Buffalo Bills -108 (DraftKings) / Indianapolis Colts -110 (bet365)
Best Total Odds: 48.0 - Under -110 (BetMGM) / Over -110 (BetMGM)

Game Info

Date: 11/10/2024
Time: 1:00 PM EST
Location: Lucas Oil Stadium (Indianapolis, IN)
TV: CBS

Buffalo Bills at Indianapolis Colts Preview

The Buffalo Bills, currently leading the AFC East with a 7-2 record, are set to face the Indianapolis Colts, who stand at 4-5, in a Week 10 matchup at Lucas Oil Stadium. The Bills have been on a roll, winning four consecutive games and showcasing one of the league's most potent offenses, led by MVP-caliber quarterback Josh Allen. Despite a slew of injuries, including key players like Amari Cooper and Keon Coleman, the Bills have managed to maintain their offensive prowess, scoring over 30 points in three straight games.

On the other side, the Colts have been struggling to find consistency this season. With Joe Flacco stepping in as the starting quarterback, Indianapolis has yet to ignite their offense, failing to score more than 20 points in their last four outings. The Colts' defense, however, has shown resilience, forcing turnovers but often unable to capitalize on them offensively. The absence of center Ryan Kelly, who was placed on injured reserve, could further complicate their offensive line dynamics against a formidable Bills defense.

Buffalo's defense, despite dealing with injuries, has been effective in piecing together strong performances, contributing to their commanding lead in the division. The Bills' ability to adapt, as seen in their strategic focus on limiting explosive plays against Miami, will be crucial against a Colts team that has struggled to find its rhythm. Indianapolis will likely rely heavily on their running game, spearheaded by Jonathan Taylor, to exploit any potential weaknesses in the Bills' run defense.

As the Bills aim to extend their winning streak and inch closer to securing the division title, the Colts are desperate to stay in the playoff hunt. The matchup promises to be a test of Buffalo's ability to maintain focus and execute their game plan against a Colts team that, despite its record, has been competitive in every game this season. With the Bills' high-scoring offense and the Colts' determination to turn their season around, this game is set to be an intriguing clash of strategies and wills.

Buffalo Bills at Indianapolis Colts Pick: Buffalo Bills Moneyline

The Buffalo Bills are poised to continue their dominant run as they face the Indianapolis Colts, and the moneyline pick for this matchup strongly favors the Bills. Buffalo has been on a tear, winning four consecutive games and establishing themselves as a powerhouse in the AFC East with a 7-2 record. Their offense, led by the MVP-caliber performance of quarterback Josh Allen, has been prolific, scoring over 30 points in three straight games. Despite injuries to key players like Amari Cooper and Keon Coleman, the Bills have shown remarkable depth and adaptability, maintaining their offensive efficiency.

In contrast, the Colts have struggled to find their footing this season, sitting at 4-5 and grappling with offensive inconsistencies. Joe Flacco's introduction as the starting quarterback has yet to spark the desired offensive resurgence, as Indianapolis has failed to score more than 20 points in their last four games. The Colts' defense, while capable of forcing turnovers, has not been able to translate those opportunities into points, further hampered by the absence of center Ryan Kelly, which could disrupt their offensive line against a formidable Bills defense.

Buffalo's defense, despite its own injury challenges, has been effective in limiting opponents, as evidenced by their strategic focus on curbing explosive plays against Miami. The Bills' ability to adapt defensively will be crucial against a Colts team that has relied heavily on their running game, led by Jonathan Taylor, to exploit any potential weaknesses. However, the Bills' overall roster strength and superior quarterback play give them a significant edge.

Given the Bills' current form, their commanding lead in the division, and the Colts' ongoing struggles, Buffalo is well-positioned to secure another victory. The Bills' high-scoring offense and strategic defensive adjustments make them the clear favorites in this matchup, supporting the pick for the Buffalo Bills on the moneyline.

Buffalo Bills at Indianapolis Colts Top Player Prop Picks

Dalton Kincaid Over 4.5 Receptions +105 (bet365)

Dalton Kincaid is poised for a high-volume game against the Indianapolis Colts, especially with the Buffalo Bills' recent trend of favoring the passing game. With key wide receivers Amari Cooper and Keon Coleman dealing with injuries, Kincaid is expected to be a primary target for Josh Allen. The Colts' defense has allowed the fourth most fantasy points to tight ends this season, making this an ideal matchup for Kincaid. His role in the offense has been significant, as he is second on the team in targets per route run. Given these factors, taking the over on Kincaid's receptions is a strong play.

Josh Allen Over 1.5 Passing TDs -115 (FanDuel)

Josh Allen has been performing at an MVP level, leading the Bills to score over 30 points in three consecutive games. Despite injuries to key receivers, Allen's ability to adapt and find alternative targets has kept the Bills' offense potent. The Colts have struggled defensively, particularly in stopping high-powered offenses, which bodes well for Allen's chances of throwing multiple touchdowns. With the Bills' offensive strategy likely focusing on exploiting the Colts' weaknesses, Allen is well-positioned to surpass the 1.5 passing touchdowns line.

Jonathan Taylor Over 80.5 Rushing Yards -110 (bet365)

Jonathan Taylor is expected to be a focal point of the Colts' offensive strategy against the Bills. With Joe Flacco under center, the Colts will likely rely heavily on their running game to control the clock and exploit the Bills' run defense, which has shown vulnerabilities, allowing 4.8 yards per carry. Taylor has a history of success against Buffalo, including a standout performance in 2021 where he rushed for 185 yards. Given the Bills' defensive focus on limiting explosive plays in the passing game, Taylor should have ample opportunities to exceed the 80.5 rushing yards line.