Week 1 of the 2025 NFL season was filled with great efforts from several running backs, and Week 2 should be no different.

With some of the lines on player rushing attempts varying across different sportsbooks, the workload for some running backs in Week 2 could lead to some big profits.

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3 Middle Bets to Consider For NFL Week 2

While there are many potential middle bets you can consider this week in the NFL, we're focusing on one specific market that seems to be producing more lines with discrepancies across books: Rushing Attempts.

It appears quite a few running backs have varying totals when it comes to their lines for Total Rushing Attempts prop bets. Here are three opportunities for middle bets that BetSmart identified:

NOTE: Odds and lines are at time of publication, and often change

1. Derrick Henry Rushing Attempts

Despite a detrimental fumble, Derrick Henry was outstanding in Week 1, and is expected to get another full workload of carries on Sunday. For this middle, bettors will hope for 20 carries for King Henry.

Game: Browns @ Ravens
Date: Sunday, September 14, 4 p.m. ET
Bet 1: Over 19.5, -120 (BetMGM)
Bet 2: Under 20.5, -122 (BetRivers)

2. Bijan Robinson Rushing Attempts

Bijan Robinson rushed just 12 times for 24 yards in Week 1, so it's expected he will tote the rock a bit more this week. It's another tight middle, but 16 carries would result in a nice profit to close out the Sunday slate of games.

Game: Falcons @ Vikings
Date: Sunday, September 14, 8:20 p.m. ET
Bet 1: Over 15.5, -114 (FanDuel)
Bet 2: Under 16.5, -113 (DraftKings)

3. Aaron Jones Rushing Attempts

Also in the Sunday Night Football game, Aaron Jones prop lines are providing another chance for a middle. Middle bettors will be hoping for 10 carries for a solid profit.

Game: Falcons @ Vikings
Date: Sunday, September 14, 8:20 p.m. ET
Bet 1: Over 9.5, +100 (Bally Bet)
Bet 2: Under 10.5, -124 (DraftKings)

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Good luck in Week 2. Onward!