Baltimore Orioles @ Cleveland Guardians Player Props, Picks and Predictions - 7/22/2025 6:40 PM EDT

We have your Baltimore Orioles @ Cleveland Guardians prop betting and game preview needs covered as the Baltimore Orioles hit the road to face the Cleveland Guardians.

Baltimore Orioles @ Cleveland Guardians Pick

Best Moneyline Odds: Cleveland Guardians -138 Bet Guardians ML, Baltimore Orioles +118 Bet Orioles ML
Best Spread Odds: Baltimore Orioles +1.5 Bet Orioles +1.5
Best Total Odds: -

Game Info

Date: 2025-07-22
Time: 6:40 PM EDT
Location: Cleveland, Ohio
TV: -

Baltimore Orioles @ Cleveland Guardians Preview

The Cleveland Guardians host the Baltimore Orioles in what promises to be an intriguing matchup. The Guardians are riding a wave of momentum, having won nine of their last eleven games, including a dominant 10-5 victory over the Orioles in Monday's series opener. This recent success has solidified their position as a formidable opponent, especially when playing at home. Cleveland boasts a 60.5% win rate (23-15) when listed as moneyline favorites, indicating their reliability in expected winning situations.

On the other side, the Baltimore Orioles are looking to bounce back from Monday's loss, which dropped their season record to 44-55. While they have shown flashes of potential, their road record of 22-29 suggests they face a challenge when away from home. The Orioles' batting average stands at .239, ranking 16th in the league, while the Guardians are slightly behind at .225. This game will test Baltimore's ability to rebound against a hot Cleveland team.

Historic Head-to-Head Stats and Analysis

Looking back at their previous encounters this season, the Baltimore Orioles managed to win two out of three games against the Cleveland Guardians back in April. However, the most recent clash saw the Cleveland Guardians secure a decisive 10-5 victory over the Orioles on Monday, July 21, 2025. This recent result indicates a shift in momentum in favor of the Guardians in their head-to-head matchups.

Pick: Cleveland Guardians Moneyline

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The Cleveland Guardians are the favored pick in this matchup, and for good reason. Their recent form is exceptional, with nine wins in their last eleven games, including a convincing victory over the Orioles just yesterday. The Guardians have proven to be a strong team when favored, winning over 60% of their games in that scenario. While the Orioles did take two of three earlier in the season, Cleveland's current momentum and home-field advantage make them the more reliable choice for this game.

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