Athletics @ St. Louis Cardinals Player Props, Picks and Predictions - 9/2/2025 7:45 PM EDT

We have your Athletics @ St. Louis Cardinals prop betting and game preview needs covered as the Athletics hit the road to face the St. Louis Cardinals.

Athletics @ St. Louis Cardinals Pick

Best Moneyline Odds: St. Louis Cardinals -105 (ESPN BET) / Oakland Athletics -104 (BetRivers)
Best Spread Odds: St. Louis Cardinals -1.5 -220 (Caesars) / Oakland Athletics +1.5 -184 (Fanduel)
Best Total Odds: Over 8.5 -104 (BetRivers) / Under 8.5 -110 (ESPN BET)

Game Info

Date: September 2, 2025
Time: 7:45 PM EDT
Location: Busch Stadium, St. Louis
TV: -

Athletics @ St. Louis Cardinals Preview

The St. Louis Cardinals (68-71) are set to host the Oakland Athletics (64-75) in what promises to be an intriguing interleague matchup at Busch Stadium. The Cardinals are navigating a challenging season, holding a 4-6 record over their last 10 games. During this stretch, they've averaged around 4.1 runs per game while conceding nearly 6 runs, highlighting struggles on both offense and defense. Their recent 3-11 home defeat to the Athletics underscores the need for a bounce-back performance in front of their home crowd. Key players for the Cardinals include Willson Contreras, Masyn Winn, and Lars Nootbaar, who will look to ignite the offense. Nolan Arenado is currently out with a shoulder injury, which impacts the Cardinals' lineup depth.

The Oakland Athletics, despite a slightly worse overall record, appear to be in more confident form, boasting a 5-5 record in their last 10 outings. They maintain an average of over 5 runs per game, giving them an offensive edge over St. Louis. Their commanding 11-3 victory over the Cardinals just yesterday signals their current strong momentum. The Athletics will be without several key players due to injury, including Nick Kurtz (Day-to-Day, Oblique), Jack Perkins (15-Day IL), Denzel Clarke (10-Day IL), Max Muncy (10-Day IL), Luis Medina (60-Day IL), Grant Holman (60-Day IL), and José Leclerc (60-Day IL).

Historic Head-to-Head Stats and Analysis

Recent head-to-head history between the Athletics and the St. Louis Cardinals shows a competitive series. The Cardinals hold a 4-3 record in their last seven head-to-head meetings against the Athletics. However, the Athletics have performed well in St. Louis, securing a 3-2 record in their last five meetings at Busch Stadium. In their last six matchups overall, the Cardinals have a 4-2 record. The most recent encounter on September 1, 2025, saw the Athletics claim a decisive 11-3 victory over the Cardinals. Looking at the broader rivalry, the Athletics boast 7 wins compared to the Cardinals' 4 in recent head-to-head matchups, with 4 of Oakland's victories coming on the road and 2 of St. Louis's wins occurring at home. The Athletics also hold a clear advantage in average scoring in these contests, averaging 5.09 runs per game compared to the Cardinals' 3 runs.

Pick: Over 8.5 Total Runs

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The total for this game is set at 8.5 runs. Considering the recent 11-3 outcome between these two teams, which resulted in 14 total runs, there's a strong indication for another high-scoring affair. Both the Athletics and the Cardinals have shown a tendency to hit the over this season, with both teams holding a 71-61-7 Over/Under record. The Athletics average over 5 runs per game, and while the Cardinals have struggled defensively, conceding nearly 6 runs per game recently, their offense is capable of contributing to the total. The combination of Oakland's recent offensive surge and St. Louis's defensive vulnerabilities makes the Over 8.5 a compelling pick.

Top Player Prop Picks

Thomas Saggese (St. Louis Cardinals) Over 0.5 Hits

Thomas Saggese has been in excellent form at the plate, hitting the over on his hits prop in 100% of his last 5 games. Over his last 10 games, he has hit the over 70% of the time, and his season-long hit rate for this prop is 57.38%. When playing at home, he has hit the over 51.52% of the time this season. Furthermore, in his only matchup against the Athletics in 2025, he recorded a hit, giving him a 100% hit rate against this opponent. With a mean of 0.79 hits per game this season against a line of 0.5, Saggese is projected to exceed this total.
Best Odds: Over 0.5 Hits at -190 (DraftKings)

Pedro Pagés (St. Louis Cardinals) Over 0.5 Hits

Pedro Pagés has demonstrated strong hitting consistency, hitting the over on his hits prop in 80% of his last 5 games and 70% of his last 10 games. His season-long hit rate for this prop stands at 58.42%. Playing at home, he has hit the over 56% of the time this season. In his single appearance against the Athletics in 2025, he also recorded a hit, showing a 100% hit rate against this opponent. With a season mean of 0.73 hits against a line of 0.5, Pagés is well-positioned to get a hit in this game.
Best Odds: Over 0.5 Hits at -165 (ESPN BET)

Luis Severino (Oakland Athletics) Over 4.5 Hits Allowed

Luis Severino has consistently allowed more than 4.5 hits in his recent outings. He has hit the over on this prop in 60% of his last 5 games and an impressive 80% of his last 10 games. For the entire season, Severino has hit the over 70.83% of the time, with a season mean of 5.79 hits allowed, which is significantly above the 4.5 line. Given his recent trends and season-long performance, it is likely he will concede at least 5 hits to the Cardinals' lineup.
Best Odds: Over 4.5 Hits Allowed at -105 (Caesars)